TY - JOUR T1 - Short-term variation of lung function and airway inflammation in children and adolescents with bronchiolitis obliterans JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA3872 VL - 48 IS - suppl 60 SP - PA3872 AU - Martin Rosewich AU - Jonas Eckrich AU - Felix Michel AU - Ralf Schubert AU - Stefan Zielen Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA3872.abstract N2 - Objectives: Bronchiolitis obliterans (BO) is a rare lung disease. Little is known about the short term variation of inflammatory markers and the lung function in patients with persistant, stable BO.Methods: Twenty patients with BO (median age=14.63, range 8.3 - 24.3) performed lung function tests, airway reversibility testing, and induction of sputum within four to six weeks. We investigated sputum cell count, inflammatory cytokines (1ß, IL-6 and IL-8) as well as lung function in patients with BO compared to healthy controls.Results: Short term variation of lung function parameters was low in patients with BO and compared to healthy controls significantly lower for FVC, FEV1, FVC/FEV1, and MEF25. Sputum cell count revealed a neutrophilic inflammation with elevated levels for IL-1ß, IL-6 and IL-8. Conclusions: Short-term variability of VCmax, FEV1, FVC and sputum neutrophilia is low in BO patients. This finding should be considered to identify successful treatment options for BO patients. ER -