RT Journal Article
SR Electronic
T1 Changes in lung function in patients with human T cell lymphotropic virus (HTLV) associated myelopathy residents in the eastern Brazilian Amazon
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4442
DO 10.1183/13993003.congress-2016.PA4442
VO 48
IS suppl 60
A1 Normando, Valeria
A1 Falcão, Luiz Fabio
A1 Vieira, Waldonio
A1 Oliveira, Robson
A1 Santos, Marcio
A1 Fuzii, Hellen
A1 Quaresma, Juarez
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4442.abstract
AB HTLV, the causative agent of HTLV-1 associated myelopathy (HAM/TSP), features obscurity to pulmonary lesions. To investigate the pulmonary function in patients who ware HAM/TSP in the Amazon. From 2013 to 2015, 19 patients who were HAM/TSP definitive, 11 who were HAM/TSP probable and 13 without HAM/TSP participated in the study and underwent a spirometry test in compliance with the standards established by the Brazilian Consensus on Spirometry (Pereira,C.A.C.J.Pneumol.2002;3:1-82).This research was approved by Ethics Committee-Instituto Evandro Chagas (292251). 18.5%(8/43) of all of the patients had obstructive or restrictive lung disease, however none was without HAM/TSP (p=0.04). Pulmonary function values were also compared. The results suggest changes in lung function in those who have developed HAM/TSP. Thus, it seems reasonable to assume that such changes may be linked to possible lung inflammation.VariablesHTLV-1 women with HAM/TSPHTLV-1 women without HAM/TSPp-valueHTLV-1 men with HAM/TSPHTLV-1 men without HAM/TSPp-valueVC2.4±0.22.6±0.10.113.4±0.74.2±0.60.08FVC2.5±0.12.7±0.10.143.4±0.74.7±0.70.01*FEV12.0±0.12.3±0.10.03*2.8±0.53.8±0.50.01*FEV1/FVC78.8±8.984.2±4.50.03*81.0±7.879.7±5.30.76FEF25-751.9±0.72.7±0.70.01*2.7±0.83.6±0.70.09FET25-750.7±0.60.5±0.10.04*0.6±0.20.6±0.10.93FEFmax4.6±1.25.8±1.20.01*6.6±1.98.6±0.60.08FEF50%2.6±1.13.5±0.90.02*3.4±0.84.6±1.10.05*FEF75%0.8±0.31.1±0.30.061.2±0.81.4±0.40.61MVV71.5±14.385.6±15.20.02*97.2±20.0139.9±22.00.00*Data are expressed as mean ± standard deviation. Student t test (p<0.05*).Tabela 01: Spirometry values of women and men who were HAM/TSP definitive and patients without HAM/TSP.