PT  - JOURNAL ARTICLE
AU  - Diver, Sarah
AU  - Kane, Binita
AU  - Ryan, Dorothy
AU  - Holmes, Leanne Jo
AU  - Fowler, Steve
AU  - Niven, Robert
TI  - Cognitive impairment in patients with eosinophilic granulomatosis with polyangiitis (EGPA): Service evaluation in a regional severe asthma centre in North-west England
AID  - 10.1183/13993003.congress-2016.PA5017
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA5017
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA5017.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA5017.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Background: Cognitive decline in EGPA is rare. 30% of patients with small vessel vasculitis may have subclinical neuropsychological impairment1. Data is limited regarding EGPA alone.Aim: To evaluate prevalence of cognitive impairment in patients with EGPA managed at a regional severe asthma centre in South Manchester, England.Methods: Cases identified where diagnosis of EGPA made by a specialist in eosinophilic vasculitis. Clinical consultations reviewed for subjective evidence of disease-related cognitive decline.Results: N = 16, 11 male, mean age 53. 25% had antibodies to myeloperoxidase (MPO). Cognitive impairment was present in 37.5% (6). Memory loss was described in all 6, poor concentration in 2, slowed speech in 1. 4 of 6 had magnetic resonance (MR) cerebral angiogram and 2 standard MR brain. Frontal white matter hyperintensities were seen on standard MR in 2. All other brain imaging was normal. 5 of 6 were reviewed by a neurologist.Discussion: Evaluation of our service indicates that disease-related cognitive impairment is more prevalent than literature suggests. Further objective evidence is required. This reinforces the importance of a multidisciplinary approach in EGPA.Reference:Frequency and patterns of subclinical cognitive impairment in patients with ANCA-associated small vessel vasculitides. Mattioli et al. J Neurol Sci. 2002.