PT - JOURNAL ARTICLE AU - Zoia Nesterenko TI - Asthma diagnosis in children with community-acquired pneumonia: New challenges AID - 10.1183/13993003.congress-2016.PA621 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA621 VI - 48 IP - suppl 60 4099 - http://erj.ersjournals.com/content/48/suppl_60/PA621.short 4100 - http://erj.ersjournals.com/content/48/suppl_60/PA621.full SO - Eur Respir J2016 Sep 01; 48 AB - Early onset asthma symptoms and community-acquired pneumonia (CAP) diagnosis in children remains relevant because of variation of symptoms, late detection and treatment, which lead to development of complications and disability in patients.Aim: To study the features of CAP clinical symptoms in children with asthma.Material: 118 children aged 1-18 years with asthma were observed.Results. In 35(29.7%) patients CAP was diagnosed. Asthma symptoms in them were more severe with longer episodes of bronchial obstruction compared with children without CAP signs: 11,5±2 days and 5,5±2,3 comparatively. Pulmonary hypertension (PH) and fibrosis (PF) in children with CAP and asthma developed in 37.1% of patients. In 38.4% of children with asthma, CAP, PH and PF CT-scans revealed emphysematous bullae (EB). In 17 of 20 patients older than 3 years, with asthma and CAP, signs of connective tissue disorders (CTD) in skeletal system (95.8%), skin (35.8%), cardiovascular (82.2%), gastrointestinal (40%), urinary system(19.5%) were determined with strong positive correlation (rxy=0.8; p«0.001) between CAP frequency and presence of CTD signs in children with asthma, that significantly complicated asthma and CAP diagnosis and caused development of complications and disability due to inadequate treatment.Conclusions: 1. One-third of asthmatic patients had CAP that led to more severe and prolonged asthma exacerbations.2. Strong positive correlation between CAP frequency and CTD signs in children with asthma was revealed.3. A variety of clinical symptoms associated with involvement of multiple systems in children with CAP and asthma in CTD process complicated diagnosis of both asthma and CAP and worsened prognosis.