RT Journal Article
SR Electronic
T1 The effects of endogenous and exogenous vitamin D on the rate of mature elastin degradation in COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4015
DO 10.1183/13993003.congress-2016.PA4015
VO 48
IS suppl 60
A1 Rob Janssen
A1 Ruben Zaal
A1 Michiel Spanbroek
A1 Jody van den Ouweland
A1 Pieter Zanen
A1 Richard Dekhuijzen
A1 Wim Janssens
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4015.abstract
AB Introduction: Two RCTs suggest that vitamin D supplementation lowers exacerbation frequency in vitamin D deficient COPD patients (Lehouck, A. et al. Ann Intern Med 2012; 156:105-14/Martineau, A.R. et al. Lancet Respir Med 2015; 3:e24-5). However, information regarding the effect of vitamin D on the rate of mature elastin degradation is lacking. We hypothesized that vitamin D supplementation in vitamin D deficient (serum 25-[OH]D<20 ng/mL) COPD patients reduces the rate of mature elastin degradation quantified by plasma desmosines levels (pDES).Methods: pDES was measured by LC-MS/MS in 142 COPD patients from the Leuven vitamin D intervention trial (100,000 IU vitamin D supplementation or placebo every 4 weeks for 1 year).Results: At baseline, no significant correlation was found between 25-[OH]D and pDES levels. No significant interaction between 25-[OH]D change and pDES change was found in the placebo arm. In the vitamin D supplementation arm, a significant negative association was found between pDES change and baseline 25-[OH]D levels (r=-0.44;p<0.001;n=56). Conclusions Endogenous vitamin D did not have an effect on the rate of mature elastin degradation. However, opposite to our hypothesis, exogenous high doses of vitamin D accelerated the rate of mature elastin degradation in vitamin D deficient COPD patients and decelerated this process in those who were vitamin D sufficient at baseline.