PT  - JOURNAL ARTICLE
AU  - Elena Koloskova
AU  - Galyna Bilyk
AU  - Tatyana Bilous
TI  - Results of cluster analysis in predicting remodeling of the bronchi in children with bronchial asthma
AID  - 10.1183/13993003.congress-2016.PA4377
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA4377
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA4377.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA4377.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Introduction: In recent years accumulated results of the study of the atopic markers, airway hyperresponsiveness and the character and activity of the local inflammatory process of the airways of asthma in childhood.Aims: Select high-risk groups on forming the bronchi remodeling to improve the management of asthma in children.Materials and methods: We examined 117 school-age children with bronchial asthma, whose average age was 11,5±0,29 years, duration of the disease was on average 5,4±0,33 years, the boys were 65.25%.Results: It was revealed 3 cluster groups of children with asthma. 1st cluster that determines moderate risk of bronchial remodeling have formed boys with early onset asthma, low index of bronchoconstriction (3.1%), high levels of interferon-γ (71,7 pg/ml) and interleukin-6 (4.27 pg/ml) in the supernatant of sputum. In the 2nd cluster, which is associated with a high risk of remodeling, have entered girls with severe asthma and later its debut, genotypes GSTM1, GSTT1, high index of bronchoconstriction (47.7%), eosinophilia in sputum (20.0%), high concentration of VEGF (400,0 pg/ml) and interleukin-13 (90.0 pg/ml) in the supernatant of sputum. 3rd cluster with low probability of irreversible changes of airways have formed children of high level of nitrogen oxide metabolites (63.9 mkmol/L) and proteolytic activity of lysis of azokol (0.24 ml/h) in exhaled air, elevated concentration of MMP-9 (6.9 pg/ml) and TNF-α (1,0 m/ml) in the supernatant of sputum.Conclusions: In spite of the detected cluster groups of school-age children with asthma it is recommended to determine the risk of airway remodeling and further tactics of the basic anti-inflammatory treatment.