TY - JOUR T1 - Prospective study analysing prevalence of XDR TB in Mumbai, India JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA2745 VL - 48 IS - suppl 60 SP - PA2745 AU - Amita Nene AU - Namrata Kewalramani AU - Vikas Agarwal Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA2745.abstract N2 - Introduction: India has a high burden of XDR TB. However the available data on XDR-TB prevalence in India has been retrospective and there is no prospective study analysing the same. Hence we conducted a prospective study to evaluate the prevalence of XDR TB in MumbaiAims: 1 To prospectively analyze the prevalence of XDR TB among TB patients in Mumbai2 To analyze the drug resistance patterns amongst these patientsMaterials: All patients who presented to our hospital with culture positive TB over the period of June 2010 to December 2011 were prospectively included in our studyResults: Total of 181 patients with positive MTB Culture were seen during our study periodOverall 152(84%) patients had pulmonary TB and 29(16%) had extra-pulmonary TBOut of 181 patients, 83 (45.8%) were found to have MDR-TB and 10 (5.5%) had XDR-TB (5 males, 5 females)All patients with XDR TB were aged between 15-44 years and 50% patients of these patients were in age group 15-24 yrsOf the 10 XDR-TB patients, 8 had pulmonary TB and 2 had extrapulmonary TB (1 lymph-node TB and 1 pleural TB)10% (1/10) of the XDR cases had never received TB treatment in the past (primary XDR TB) and 90% (9/10) of the XDR TB cases had received prior TB treatment (acquired XDR TB)Analysis of drug resistance patterns showed least resistance to Pyrazinamide (70%) amongst first line TB drugs, and to clofazimine (0%) and PAS (60%) amongst second line drugsConclusion: This is the only prospective study evaluating prevalence of XDR TB in India. Prevalence of XDR-TB was found to be 5.5% among all TB cases and 12% among MDR-TB cases. All patients of XDR TB in our study were below 45 years of age and no resistance to Clofazimine was seen in the 10 XDR cases. ER -