PT - JOURNAL ARTICLE AU - Claire Hodgekiss AU - S. Hasan Arshad AU - Graham Roberts AU - Elinor Jenkins AU - Ramesh Kurukulaaratchy TI - Characterisation of lung function at 18 by early life wheeze phenotype AID - 10.1183/13993003.congress-2016.PA4595 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA4595 VI - 48 IP - suppl 60 4099 - http://erj.ersjournals.com/content/48/suppl_60/PA4595.short 4100 - http://erj.ersjournals.com/content/48/suppl_60/PA4595.full SO - Eur Respir J2016 Sep 01; 48 AB - The influence of early life wheezing phenotype on lung function in young adult wheezers is unknown. To assess this, the Isle of Wight Birth Cohort (n=1,456) was reviewed at 1, 2, 4, 10 and 18-years with recording of lung function at 10 and 18-years. At 10-years, 4 wheeze phenotypes were defined. Non-Wheezers (NW) had no wheeze at any point, Early-Transient-Wheezers (ETW) wheezed in the first 4 years of life but not at 10, Persistent-Wheezers (PW) wheezed in the first 4 years of life and at 10-years while Late-Onset-Wheezers demonstrated no wheeze in the first 4 years of life but had developed it by age 10. We focused on participants still wheezing at 18 (n= 211), assessing their 18-year lung function to their original wheeze phenotype at 10-years. All phenotypes were compared to each other and p values adjusted. Of those wheezing at 18, 31% were originally NW, 17% ETW, 30% PW and 20% LW at 10 years.Those originally PW (0.81) showed significantly greater airflow limitation than NW (0.87 p=0.012) and ETW (0.87 p=0.048) in terms of FEV1/FVC and compared to ETW (3.58L/S vs 4.29L/S p=0.0240) and LW (4.29L/S p=0.048) in terms of FEF25/75%. The change in small airway calibre from 10 to 18 years was also significantly less in PW (1.4L/S) compared to LW (2.1L/S p<0.001), suggesting that despite both groups wheezing by 10, they are already set on different growth trajectories. Both PW (1.4) and LW (1.4) showed greater bronchial hyperresponsiveness (Log10 (DRS+10)) at 18 when compared to NW (1.1, p=0.024 and p=0.036 respectively) and at 10 PW (1.9) and LW (1.9) to NW (1.4, p<0.001). These findings should raise awareness of the detrimental consequence of early persistent wheeze on adult lung function.