RT Journal Article
SR Electronic
T1 The impact of CPAP on circulating IGF-1 in patients with OSAS
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3421
DO 10.1183/13993003.congress-2016.PA3421
VO 48
IS suppl 60
A1 Andreas Palm
A1 Christian Berne
A1 Helena Igelström
A1 Pernilla Åsenlöv
A1 Christer Janson
A1 Eva Lindberg
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA3421.abstract
AB Background: Obstructive sleep apnea syndrome (OSAS) is a disease with metabolic consequences and is associated with decreased levels of insulin-like growth factor-1 (IGF-1).Aim: To investigate whether continuous positive airway pressure (CPAP) increase IGF-1 in patients with OSAS.Methods: Consecutive patients with OSAS were recruited from a sleep clinic and IGF-1 was measured before initiation of CPAP and at follow-up after 4.8±2.4 months. Patients compliant to CPAP treatment (usage >4 hours/night) were compared with those considered to be non-compliant (usage <4 hours/night).Results: Complete data were obtained from 70 subjects (men 85.7%, age 55.8±11.9 years, apnea-hypopnea index (AHI) 42.5±21.1, Epworth sleepiness scale (ESS) 12.2±4.5). In those compliant to CPAP (n=41), there was an increase in IGF-1 with 22.1±25.3 ng/ml compared to 2.3±23.4 ng/ml in the non-compliant group (n=29) (P=0.0014). In multivariate analysis adjusting for gender, age, body mass index (BMI), average saturation during the night recording and AHI, there was a correlation between an increase in IGF-1 levels and compliance to CPAP (β-coefficient 27.4; 95% CI: 15.4-39.4), change in BMI (β-coefficient -6.8; 95% CI: -11.1- -2.6) and change in HbA1c (β-coefficient -1.7; 95 CI: -3.3- -0.06).Conclusion: CPAP >4 hours/night increases serum levels of IGF-1 in patients with OSAS.