TY - JOUR T1 - Inflammation and primary graft dysfunction after lung transplantation: CT-PET findings JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA4641 VL - 48 IS - suppl 60 SP - PA4641 AU - Davide Chiumello AU - Miriam Gotti AU - Chiara Chiurazzi AU - Mariateresa Guanziroli AU - Matteo Brioni AU - Bijan Safaee Fakhr AU - Andrea Colombo AU - Dario Massari AU - Antonio Cammaroto AU - Felicia Zito AU - Massimo Cressoni Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA4641.abstract N2 - Background The leading cause of early mortality after lung transplantation is primary graft dysfunction (PGD). The inflammation seems to play a central role in PGD development.Aims and objectives To find out whether lungs metabolic activity was related to PGD development.Methods We designed a prospective observational study in which patients who underwent lung transplantation performed a CT-PET study within 1 week after surgery. We measured the lungs metabolic activity and the inflation status.Results Twenty-four patients were enrolled: 10 after double- and 14 after single-lung transplantation. Within 5[4-6] days after lung transplantation, the grafts showed a [18F]FDG uptake rate (mLblood/mLtissue/min) of 26[18-33]*10-4 (reference values 11[7-15]*10-4)1. The [18F]FDG uptake rate was inversely related to the time elapsed from surgery (R2=0.28, p=0.001).Nine patients developed PGD. The grafts of patients who developed PGD showed: similar [18F]FDG uptake rate (28[18-26]*10-4 vs 26[22-31]*10-4, p=0.79), higher not-inflated (28[20-38]% vs 14[7-21]%, p=0.01) and lower well-inflated tissue fraction (29[25-41]% vs 53[39-65]%, p<0.01) than grafts of patients who did not. Conclusions As all the grafts showed increased [18F]FDG uptake rate, independently on PGD, the hydrostatic component more than inflammation could play a role in its development.Reference 1. Bellani G. et al, Am J Respir Crit Care Med 2011; 183: 1193–9. ER -