TY - JOUR T1 - ALOX15 gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease (AERD) JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA1196 VL - 48 IS - suppl 60 SP - PA1196 AU - Ryosuke Souma AU - Kenya Koyama AU - Akemi Koyama AU - Shyuzo Abe AU - Junichiro Morioka AU - Kei Sugitate AU - Takayoshi Fujimatsu AU - Hajime Arifuku AU - Kentaro Nakano AU - Tomoshige Wakayama AU - Hideyuki Satoh AU - Hirokuni Hirata AU - Kumiya Sugiyama Sugiyama AU - Yasutsugu Fukushima Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA1196.abstract N2 - AERD is known to be exacerbated by ingestion of non-steroidal anti-inflammatory drug(NSAID).AERD patients are commonly found in female, and their asthmatic symptoms tend to be chronic and severe.However, the pathophysiologic mechanisms of this specific asthma phenotype have not yet been fully understood.In this study, we examined the ALOX15 gene polymorphisms (rs2664593 and rs7217186) in a Japanese adult population.Methods: DNA specimens were obtained from the following three groups:70 patients with AERD, 70 patients with aspirin-tolerant asthma(ATA), and 70 normal controls.Allelic discrimination assay for single nucleotide polymorphisms(SNPs) relating to the ALOX15 gene expression was carried out by using previously described SNPs detective system, SSTEC.Results: The frequencies of the GG genotype of ALOX15(rs2664593) were higher than those of the GC/CC genotype in AERD patients compared to ATA patients and controls(P<0.001 and P<0.001, respectively ).In female AERD patients, but not in males, frequencies of the GG genotype were higher than those of the GC/CC genotype of ALOX15 compared to female ATA patients and controls (P=0.006 and P<0.001).The frequencies of genotype of ALOX15 (rs7217186) were not different between AERD and ATA or controls.Comparison of the clinical characteristics in AERD patients according to the ALOX15 gene polymorphisms showed that total serum IgE and peripheral eosinophils were not different between the polymorphisms.Conclusions: We were the first to analyze ALOX15 gene polymorphism in Japanese patients with AERD, and showed that ALOX15 gene polymorphism in Japanese patients with AERD is different from that in the patients with ATA. ER -