RT Journal Article
SR Electronic
T1 Study of prevalence & ultrasonographic characteristics of carotid plaques in patients with COPD: An Indian perspective
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3798
DO 10.1183/13993003.congress-2016.PA3798
VO 48
IS suppl 60
A1 Manas Mengar
A1 Madhav Kale
A1 Parag Khatavkar
A1 Kedar Korde
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA3798.abstract
AB Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a multisystem disorder with extra-pulmonary manifestations like cardiovascular and cerebrovascular co-morbidities which are associated with higher prevalence of carotid plaques. Mean Carotid Intima-Media Thickness (cIMT) and morphological plaque characterisation1 into Types 1, 2, 3 and 4 using carotid ultrasonography are validated methods that can predict future vascular events. Types 1 and 2 are unstable and vulnerable to rupture.Aim: To determine the carotid plaque prevalence, mean cIMT and morphologic types among elderly Indian COPD patients and control subjects.Methods: A total of 51 COPD and 54 Control subjects were evaluated. Diagnosis of COPD was confirmed on spirometry. All study subjects underwent Carotid doppler ultrasound. Plaque was defined as cIMT>1.2mm and at least 50% thicker than the neighbouring segments. Mean cIMT values were computed & plaque morphological characterisation was determied using standardized ultrasonography protocols.Result:1.)Among 51 COPD patients plaques were found in 26(51%) patients compared to 15(28%) in controls.(p=0.017)2.)Average mean cIMT in COPD patients was 1.11mm and 0.83mm in Controls.(p=0.003).3.)Type 1 & Type 2 plaques were found in 31.3% & 35% in COPD patients compared to 14.8% & 9.2% in Control Subjects respectively.Conclusion: There is raised average mean cIMT and higher prevalence of unstable Type 1 and Type 2 plaques found in COPD patients. These predisposes them to higher risk of future cerebrovascular events.References: 1. Edward I., et al. The Extracranial Cerebral vessels. Diagnostic Ultrasound 4th edition. Elsevier Mosby Inc. USA. 2011; 25; 950-965.