RT Journal Article
SR Electronic
T1 Clinical characteristics of patients with frequent COPD exacerbations in a Swiss multicenter COPD cohort study (TOPDOCS)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3952
DO 10.1183/13993003.congress-2016.PA3952
VO 48
IS suppl 60
A1 Henny, Simona
A1 Dieterle, Thomas
A1 Brack, Thomas
A1 Brutsche, Martin
A1 Clarenbach, Christian
A1 Irani, Sarosh
A1 Frey, Martin
A1 Sievi, Noriane
A1 Thurnheer, Robert
A1 Kohler, Malcom
A1 Leuppi, Jörg
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA3952.abstract
AB Background and Importance: Chronic obstructive pulmonary disease (COPD) exacerbations may be linked to serious consequences. They contribute to disease progression, worsening health status, more hospitalization and are directly linked to COPD-related mortality. Some patients are at particularly high risk. However, the individual risk of exacerbation is difficult to determine.Objective: The goal of this study was to investigate the value of clinical characteristics as predictors of frequent exacerbations (=/> 2/y).Methods: In 270 patients (mean age 63 ± years; 67% male) with COPD enrolled in The Obstructive Pulmonary Disease Outcomes Cohort of Switzerland (TOPDOCS) different clinical parameters were measured. Differences between COPD patients with frequent (≥2 per year) and less frequent (0-1 per year) exacerbations were assessed.Results: The ANOVA-p-values of different clinical parameters are shown in the following tables:parameterP (ANOVA)GOLD (Global Initiative for Chronic Obstructive Lung Disease)0.000COPD Assessment Test0.000MMRC (Modified Medical Research Council dyspnea scale)0.000Short Form-6 dimension V1 questionnaire0.000Short Form-6 dimension V2 questionnaire0.000TABLE 1 parameterP (ANOVA)weight (kg)0.004heart rate (bpm)0.000sO2 (%)0.023FEV1/FVCex Post % Soll0.000Thrombocytes (x10^9/l)0.002Bilirubin (μmol/l)0.007TABLE 2 Conclusions: The GOLD-classification, CAT-score, MMRC-score and the SF-6D V1 and V2 are significantly associated with exacerbation risk. Also the weight, heart rate, 02-saturation, lung function parameters, the thrombocytes and bilirubin-value appear to contribute further to the prediction of frequent exacerbations.