PT  - JOURNAL ARTICLE
AU  - Henny, Simona
AU  - Dieterle, Thomas
AU  - Brack, Thomas
AU  - Brutsche, Martin
AU  - Clarenbach, Christian
AU  - Irani, Sarosh
AU  - Frey, Martin
AU  - Sievi, Noriane
AU  - Thurnheer, Robert
AU  - Kohler, Malcom
AU  - Leuppi, Jörg
TI  - Clinical characteristics of patients with frequent COPD exacerbations in a Swiss multicenter COPD cohort study (TOPDOCS)
AID  - 10.1183/13993003.congress-2016.PA3952
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA3952
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA3952.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA3952.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Background and Importance: Chronic obstructive pulmonary disease (COPD) exacerbations may be linked to serious consequences. They contribute to disease progression, worsening health status, more hospitalization and are directly linked to COPD-related mortality. Some patients are at particularly high risk. However, the individual risk of exacerbation is difficult to determine.Objective: The goal of this study was to investigate the value of clinical characteristics as predictors of frequent exacerbations (=/> 2/y).Methods: In 270 patients (mean age 63 ± years; 67% male) with COPD enrolled in The Obstructive Pulmonary Disease Outcomes Cohort of Switzerland (TOPDOCS) different clinical parameters were measured. Differences between COPD patients with frequent (≥2 per year) and less frequent (0-1 per year) exacerbations were assessed.Results: The ANOVA-p-values of different clinical parameters are shown in the following tables:parameterP (ANOVA)GOLD (Global Initiative for Chronic Obstructive Lung Disease)0.000COPD Assessment Test0.000MMRC (Modified Medical Research Council dyspnea scale)0.000Short Form-6 dimension V1 questionnaire0.000Short Form-6 dimension V2 questionnaire0.000TABLE 1 parameterP (ANOVA)weight (kg)0.004heart rate (bpm)0.000sO2 (%)0.023FEV1/FVCex Post % Soll0.000Thrombocytes (x10^9/l)0.002Bilirubin (μmol/l)0.007TABLE 2 Conclusions: The GOLD-classification, CAT-score, MMRC-score and the SF-6D V1 and V2 are significantly associated with exacerbation risk. Also the weight, heart rate, 02-saturation, lung function parameters, the thrombocytes and bilirubin-value appear to contribute further to the prediction of frequent exacerbations.