TY - JOUR T1 - Do typical and atypical HRCT patterns make difference in prognosis of patients with IPF? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA795 VL - 48 IS - suppl 60 SP - PA795 AU - Martina Vašáková AU - Martina Sterclova AU - Vladimir Bartos AU - Martina Doubkova AU - Martina Plackova AU - Monika Zurkova AU - Vladimira Lostakova AU - Ladislav Lacina AU - Vladimir Rihak AU - Frantisek Petrik AU - Pavlina Lisa AU - Radka Bittenglova AU - Richard Tyl AU - Gustav Ondrejka AU - Hana Suldova AU - Jaroslav Lnenicka AU - Jana Psikalova AU - Tomas Snizek AU - Jiri Homolka AU - Renata Kralova AU - Jan Kervitzer AU - Michal Svoboda AU - Jana Strenkova AU - Athol Wells Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA795.abstract N2 - AIMS: Idiopathic pulmonary fibrosis (IPF) is characterized by radiologic pattern of usual interstitial pneumonia (UIP) with honey-combing reflecting end-stage of the disease. Nevertheless significant part of patients with IPF does not present with typical UIP pattern. In our study we investigated whether HRCT pattern can influence course of the disease and prognosis of IPF patients.METHODS: Our retrospective study was based on the data from the Czech part of the EMPIRE registry (European Multipartner IPF registry). 513 patients were stratified according HRCT pattern to the groups: UIP (423), possible UIP (71) and inconsistent with UIP (19). Survival from the diagnosis up to 84 months was evaluated by Kaplan-Meier curve and statistical significance tested by Log Rank test. The vital capacity (VC) and transfer factor (TLCO) initial values and their decline in 6, 12, and 18 months were compared between the groups using t-test. P value less than 0.05 was considered statistically significant.RESULTS: The Kaplan-Meier survival curves did not show a difference between UIP, possible UIP and inconsistent with UIP groups. The median survival showed no difference between the groups as well (52, 56.9 and 56.5 months resp.). The FVC and TLCO values showed no difference at the time of diagnosis and had the same rate of decline in 6, 12 and 18 months in UIP, possible UIP and inconsistent with UIP groups.CONCLUSIONS: Our results show that IPF patients with atypical HRCT pattern have the same prognosis as those with typical UIP pattern. It does mean that these patients should be treated the same way as the cases with typical HRCT UIP pattern.The study was supported by grant NT 13433-4/2012, IGA MZCR. ER -