PT  - JOURNAL ARTICLE
AU  - Ilgar Mustafayev
TI  - The impact of chlamydial infection on the course of bronchiolitis obliterans in children
AID  - 10.1183/13993003.congress-2016.PA1271
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA1271
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA1271.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA1271.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Objective: To evaluate the effect Chlamidiae pneumoniae on clinical and immunological parameters in children with chronic bronchiolitis obliteransMaterials and Methods: 106 children with COPD were examined at the age from 1 year to 15 years. In 47 patients the results of research on chlamydial infection were positive. The concentration of specific IgG and IgM to Clamydiae pneumoniae were determined by enzyme immunoassay.The method of indirect immunofluorescence for the presence of membrane antigens assessed phenotypic composition of peripheral blood lymphocytes (CD3, CD4, CD8).Results: In patients with chlamydial infection clinic during exacerbation was characterized by the brightness of displays. The symptoms of intoxication were pronounced. Bronchoobstructive syndrome (BOS): shortness of breath, spastic paroxysmal cough, part of the auxiliary muscles in the act of breathing on a background of low grade or febrile temperature comes to the fore. Auscultation listened to the mass of dry whistling and buzzing and wet wheezing. Radiographs of the chest determines the gain and distortion bronchopulmonary figure, extension roots phenomenon peribronhita. However, the duration of these symptoms was short. IgG concentration in Chlamidiae pneumonia in the acute stage of -0,65 ± 0,04, in remission-0.2 ± 0,05 n =. 0-0,257. The level of IgM to Chlamidiae pneumonia: 0,5 ± 0,01 and 0,06 ± 0,01pri n = 0-0,173Conclusion: The presence of chlamydial infection in the genesis of the disease contributes to a prolonged course of bronchial obstruction syndrome with frequent recurrent relapses. There was moderate cell type immunosuppression.