RT Journal Article
SR Electronic
T1 Evolution of COPD phenotypes in time - Czech multicentre research database of severe COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4179
DO 10.1183/13993003.congress-2016.PA4179
VO 48
IS suppl 60
A1 Vladimír Koblízek
A1 Barbora Novotna
A1 Jan Svancara
A1 Michal Svoboda
A1 Patrice Popelkova
A1 Marek Plutinsky
A1 Kristian Brat
A1 Jaromir Zatloukal
A1 Eva Volakova
A1 Karel Hejduk
A1 Eva Kocova
A1 Michal Kopecky
A1 Katerina Neumannova
A1 Miroslava Fecaninova
A1 Petr Safranek
A1 Tomas Dvorak
A1 Ondrej Sobotik
A1 Zuzana Liptakova
A1 Lucie Heribanova
A1 Blanka Snelerova
A1 Marie Majerciakova
A1 Pavlina Musilova
A1 Jiri Jarkovsky
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4179.abstract
AB Background: COPD is a condition with several clinical variants:non-exacerbation phenotype(NON-AE),frequent exacerbations with chronic bronchitis(AE CB),frequent exacerbations without chronic bronchitis(AE NON-CB),and asthma–COPD overlap syndrome(ACOS).The evolution of COPD phenotypes in time and their impact on lung function and symptoms remains largely unknown.Methods: The Czech Research Database of COPD(NCT01923051)is a multicentre,observational,and prospective study of consecutive patients with severe COPD.Signs identifying phenotypes, lung function, and respiratory symptoms were assessed annually.Results: 647 severe COPD subjects were enrolled until Jan 16. 113 of them were eligible for two-year analysis (66.8±9.1yrs,73.8% males,post-BD FEV1 43.0±17.7%).On the whole 62.6% were NON-AE,18.8% were AE CB, 7.1% were AE NON-CB,and 11.5 % were ACOS subjects.We found apparent differences in term of COPD phenotypes stability during follow-up.There were stable (ACOS,and NON-AE) and unstable (AE CB, and AE NON-CB) phenotypes (Fig1). With respect to changes of lung function and symptoms we noted significant differences between above mentioned phenotypes.Conclusion: Two clinical phenotypes (ACOS and NON-AE) of subjects with severe COPD we can described as stable over time.Significant differences in FEV1 declination and symptoms evolution between different COPD phenotypes in the prospective two-year evaluation were noted.