PT  - JOURNAL ARTICLE
AU  - Vladimír Koblízek
AU  - Barbora Novotna
AU  - Jan Svancara
AU  - Michal Svoboda
AU  - Patrice Popelkova
AU  - Marek Plutinsky
AU  - Kristian Brat
AU  - Jaromir Zatloukal
AU  - Eva Volakova
AU  - Karel Hejduk
AU  - Eva Kocova
AU  - Michal Kopecky
AU  - Katerina Neumannova
AU  - Miroslava Fecaninova
AU  - Petr Safranek
AU  - Tomas Dvorak
AU  - Ondrej Sobotik
AU  - Zuzana Liptakova
AU  - Lucie Heribanova
AU  - Blanka Snelerova
AU  - Marie Majerciakova
AU  - Pavlina Musilova
AU  - Jiri Jarkovsky
TI  - Evolution of COPD phenotypes in time - Czech multicentre research database of severe COPD
AID  - 10.1183/13993003.congress-2016.PA4179
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA4179
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA4179.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA4179.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Background: COPD is a condition with several clinical variants:non-exacerbation phenotype(NON-AE),frequent exacerbations with chronic bronchitis(AE CB),frequent exacerbations without chronic bronchitis(AE NON-CB),and asthma–COPD overlap syndrome(ACOS).The evolution of COPD phenotypes in time and their impact on lung function and symptoms remains largely unknown.Methods: The Czech Research Database of COPD(NCT01923051)is a multicentre,observational,and prospective study of consecutive patients with severe COPD.Signs identifying phenotypes, lung function, and respiratory symptoms were assessed annually.Results: 647 severe COPD subjects were enrolled until Jan 16. 113 of them were eligible for two-year analysis (66.8±9.1yrs,73.8% males,post-BD FEV1 43.0±17.7%).On the whole 62.6% were NON-AE,18.8% were AE CB, 7.1% were AE NON-CB,and 11.5 % were ACOS subjects.We found apparent differences in term of COPD phenotypes stability during follow-up.There were stable (ACOS,and NON-AE) and unstable (AE CB, and AE NON-CB) phenotypes (Fig1). With respect to changes of lung function and symptoms we noted significant differences between above mentioned phenotypes.Conclusion: Two clinical phenotypes (ACOS and NON-AE) of subjects with severe COPD we can described as stable over time.Significant differences in FEV1 declination and symptoms evolution between different COPD phenotypes in the prospective two-year evaluation were noted.