PT - JOURNAL ARTICLE AU - Trojova, Ivana AU - Kozarova, Miriam AU - Petrasova, Darina AU - Malachovska, Zuzana AU - Paranicova, Ivana AU - Tkac, Ivan AU - Joppa, Pavol AU - Pobeha, Pavol AU - Tkacova, Ruzena TI - Effects of continuous positive airway pressure on arterial stiffness and oxidative stress in patients with obstructive sleep apnoea AID - 10.1183/13993003.congress-2016.PA3062 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA3062 VI - 48 IP - suppl 60 4099 - http://erj.ersjournals.com/content/48/suppl_60/PA3062.short 4100 - http://erj.ersjournals.com/content/48/suppl_60/PA3062.full SO - Eur Respir J2016 Sep 01; 48 AB - Backround: Obstructive sleep apnoea (OSA) is associated with increased arterial stiffness and endothelial dysfunction. OSA-related oxidative stress, systemic inflammation and endotoxemia may play a role in vascular derangements.Aims: We investigated effects of continuous positive airway pressure (CPAP) therapy on arterial stiffness, body composition, endotoxemia and oxidative stress.Methods: 40 subjects with OSA [age (mean±SD) 50±8 years, body mass index (BMI) 31.9±4.5 kg/m2] free of cardiovascular diseases except for arterial hypertension were enrolled. Arterial stiffness was assessed by carotid-radial pulse wave velocity (PWV) (Complior®, France), body composition by measuring bioelectrical impedance (Bodystat 1500, UK). PWV, body composition, serum lipopolysaccharides-binding protein (LBP) and oxidized low-density lipoprotein (oxLDL), were measured at baseline and after 3 months of CPAP.Results: Compliance with CPAP was 4.1±1.8 hours/night. Reductions of PWV in association with reductions in oxLDL were observed after 3 months of CPAP (9.7±1.6 to 9.0±1.6 m/s, p=0.003; 501±186 to 381±174 ng/ml, p=0.002, respectively). Improvements in arterial stiffness were observed regardless body weight or body composition change. CPAP had no effect on an endotoxemia marker (serum LBP).Conclusions: Our results suggest that in patients with OSA without overt cardiovascular diseases, elimination of OSA by CPAP results in improvements in arterial stiffness in association with reductions in oxidative stress.Support: APVV-0134-11, VEGA 1/0863/15 and 1/0208/16, Ministry of Education, Slovakia.