PT  - JOURNAL ARTICLE
AU  - Ivana Trojova
AU  - Miriam Kozarova
AU  - Darina Petrasova
AU  - Zuzana Malachovska
AU  - Ivana Paranicova
AU  - Ivan Tkac
AU  - Pavol Joppa
AU  - Pavol Pobeha
AU  - Ruzena Tkacova
TI  - Effects of continuous positive airway pressure on arterial stiffness and oxidative stress in patients with obstructive sleep apnoea
AID  - 10.1183/13993003.congress-2016.PA3062
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA3062
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA3062.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA3062.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Backround: Obstructive sleep apnoea (OSA) is associated with increased arterial stiffness and endothelial dysfunction. OSA-related oxidative stress, systemic inflammation and endotoxemia may play a role in vascular derangements.Aims: We investigated effects of continuous positive airway pressure (CPAP) therapy on arterial stiffness, body composition, endotoxemia and oxidative stress.Methods: 40 subjects with OSA [age (mean±SD) 50±8 years, body mass index (BMI) 31.9±4.5 kg/m2] free of cardiovascular diseases except for arterial hypertension were enrolled. Arterial stiffness was assessed by carotid-radial pulse wave velocity (PWV) (Complior®, France), body composition by measuring bioelectrical impedance (Bodystat 1500, UK). PWV, body composition, serum lipopolysaccharides-binding protein (LBP) and oxidized low-density lipoprotein (oxLDL), were measured at baseline and after 3 months of CPAP.Results: Compliance with CPAP was 4.1±1.8 hours/night. Reductions of PWV in association with reductions in oxLDL were observed after 3 months of CPAP (9.7±1.6 to 9.0±1.6 m/s, p=0.003; 501±186 to 381±174 ng/ml, p=0.002, respectively). Improvements in arterial stiffness were observed regardless body weight or body composition change. CPAP had no effect on an endotoxemia marker (serum LBP).Conclusions: Our results suggest that in patients with OSA without overt cardiovascular diseases, elimination of OSA by CPAP results in improvements in arterial stiffness in association with reductions in oxidative stress.Support: APVV-0134-11, VEGA 1/0863/15 and 1/0208/16, Ministry of Education, Slovakia.