TY - JOUR T1 - Association between adipokines, inflammatory markers and systemic manifestations in chronic obstructive pulmonary disease (COPD) patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA4615 VL - 48 IS - suppl 60 SP - PA4615 AU - Carolina Mesquita AU - Robson Prudente AU - Laura Caram AU - Caroline Knaut AU - Estefânia Franco AU - Duelene Ludimila Nogueira AU - Liana Coelho AU - Irma Godoy AU - Suzana Minamoto Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA4615.abstract N2 - Introduction: Recent studies have shown that adipose tissue can contributes to increase systemic inflammation and can be associated to systemic manifestations in COPD.Objectives: The aim of this study was to evaluate adipokines and systemic inflammation COPD patients.Methods: We evaluated 59 mild to very severe COPD patients according to GOLD. Clinical and laboratory evaluation, pre-and post-bronchodilator spirometry, pulse oximetry, body mass index - BMI, fat-free mass - FFM and FFF index, six minute walk distance (6MWD), health status (St. George Respiratory Disease Questionnaire SGRQ and Hospital Anxiety and Depression Scale HAD) were evaluated. Concentrations of interleukin 6 (IL-6), C-reactive protein (CRP), adiponectin and leptin were measured in serum.Results: 13.6% of patients were mild COPD, 45.7% moderate, 25.4% severe and 15.3% very severe. When patients were categorized according to BODE index, adipokines and others systemic inflammation did not differ between groups. However, when categorized according to GOLD, patients with moderate [0.27 (0.20-0.29) vs 0.53 (0.43-0.61) p=0,002] and severe [0.27 (0.20-0.29) vs 0.47 (0.38-0.61) p=0,018] COPD showed higher leptin concentrations than mild COPD. We identified negative correlation of leptin with age (R= -0.41, p=0.001), and positive association of leptin with BMI (R= 0.600, p= <0.001) and CRP (R= 0.322, p=0.02). 6MWD showed negative correlation with CRP (R= -0.341, p=0.03) and adiponectin (R= -0303, p=0.04).Conclusion: Increased adipokines and inflammatory markers were correlated with body composition and exercise capacity in COPD patients. ER -