RT Journal Article
SR Electronic
T1 Association between adipokines, inflammatory markers and systemic manifestations in chronic obstructive pulmonary disease (COPD) patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4615
DO 10.1183/13993003.congress-2016.PA4615
VO 48
IS suppl 60
A1 Mesquita, Carolina
A1 Prudente, Robson
A1 Caram, Laura
A1 Knaut, Caroline
A1 Franco, Estefânia
A1 Nogueira, Duelene Ludimila
A1 Coelho, Liana
A1 Godoy, Irma
A1 Minamoto, Suzana
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4615.abstract
AB Introduction: Recent studies have shown that adipose tissue can contributes to increase systemic inflammation and can be associated to systemic manifestations in COPD.Objectives: The aim of this study was to evaluate adipokines and systemic inflammation COPD patients.Methods: We evaluated 59 mild to very severe COPD patients according to GOLD. Clinical and laboratory evaluation, pre-and post-bronchodilator spirometry, pulse oximetry, body mass index - BMI, fat-free mass - FFM and FFF index, six minute walk distance (6MWD), health status (St. George Respiratory Disease Questionnaire SGRQ and Hospital Anxiety and Depression Scale HAD) were evaluated. Concentrations of interleukin 6 (IL-6), C-reactive protein (CRP), adiponectin and leptin were measured in serum.Results: 13.6% of patients were mild COPD, 45.7% moderate, 25.4% severe and 15.3% very severe. When patients were categorized according to BODE index, adipokines and others systemic inflammation did not differ between groups. However, when categorized according to GOLD, patients with moderate [0.27 (0.20-0.29) vs 0.53 (0.43-0.61) p=0,002] and severe [0.27 (0.20-0.29) vs 0.47 (0.38-0.61) p=0,018] COPD showed higher leptin concentrations than mild COPD. We identified negative correlation of leptin with age (R= -0.41, p=0.001), and positive association of leptin with BMI (R= 0.600, p= <0.001) and CRP (R= 0.322, p=0.02). 6MWD showed negative correlation with CRP (R= -0.341, p=0.03) and adiponectin (R= -0303, p=0.04).Conclusion: Increased adipokines and inflammatory markers were correlated with body composition and exercise capacity in COPD patients.