TY - JOUR T1 - Influence of modern basic therapy of bronchial asthma (BA) on the course of pulmonary TB in patients with pulmonary TB associated with asthma JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA2705 VL - 48 IS - suppl 60 SP - PA2705 AU - Galina Kuklina AU - Evgeny Smelev Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA2705.abstract N2 - Aim: To study influence of basic therapy of BA on the course of pulmonary TB.We studied influence of modern basic therapy of BA on the course of pulmonary TB in 43 cases of pulmonary TB associated with BA: 15 cases of focal TB, 13 cases of infiltrative TB (IT), 12 cases of fibrocavernous TB (FCT). All the patients received standard treatment for the main disease with TB drugs, as recommended by the WHO. 24 patients received combined therapy with inhaled glucocorticosteroids (IGCS) based on severity of asthma – one dose of 50/500 mcg of combined IGCS (including prolonged salmeterol and fluticasone propionate) twice a day, during 6 months. 19 controls received euphyllin and short-range β2-agonists. Mycobacterial burden was evaluated in the beginning of the study, and monthly during 6 months; it was estimated in per cents from the total number of patients. Chest CT was performed in the beginning of the study, after 3 and 6 months, and was measured in scores. Clinical symptoms (dyspnea, cough, mycobacteria burden, rales, night asphyxia) were estimated by a 4-score scale and followed by calculation of the cumulative index.We established that basic therapy of BA accelerated sputum conversion in patients with IT by 16.8%, in patients with FCT – by 14.8%. Infiltration expressiveness in the lung tissue decreased by 63.81% in IT; cavities closed by 44.11%. CI decreased by 29.3% in the main group, while by 12.4% in the comparison group.Conclusion: Basic therapy of BA accelerates sputum conversion, does not influence X-ray changes in the lungs and significantly improves respiratory symptoms in patients with pulmonary TB associated with BA. ER -