RT Journal Article
SR Electronic
T1 Evaluation of fatigue state with virus-related novel biomarkers in obstructive lung diseases
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA5011
DO 10.1183/13993003.congress-2016.PA5011
VO 48
IS suppl 60
A1 Yumi Kaneko
A1 Katsutoshi Nakayama
A1 Nayuta Saito
A1 Kazuya Tsubouchi
A1 Naoko Sato
A1 Masahiro Yoshida
A1 Yusuke Kurita
A1 Kenji Kobayashi
A1 Hirofumi Utsumi
A1 Haruhiko Yanagisawa
A1 Mitsuo Hashimoto
A1 Hiroshi Wakui
A1 Syunsuke Minagawa
A1 Atsushi Kojima
A1 Hiromichi Hara
A1 Takanori Numata
A1 Jun Araya
A1 Kazuyoshi Kuwano
A1 Nobuyuki Kobayashi
A1 Kazuhiro Kondo
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA5011.abstract
AB Background Fatigue is an important clinical state and limits physical, mental activities in the patients with chronic lung diseases. However mechanisms and evaluation methods of fatigue are not well established. Recently reactivation of human herpesvirus (HHV)6/7 and HHV6 related molecules, named SITH-1 (Small protein encoded by the Intermediate Stage Transcript of HHV6-1) and its serum antibody (aSITH-1Ab) have been studied as novel biomarkers for fatigue.1),2) Fatigue due to chronic stress can cause increase of HHV6/7 DNAs in saliva, and aSITH-1Ab in blood of patients with mental disturbance. The HHV-related biomarkers could be good candidates to evaluate the pathological fatigue.Method To evaluate fatigue state, patients in stable conditions with COPD, asthma (BA) and BA COPD overlap syndrome (ACOS) were enrolled. The fatigue markers, depression score, and inflammation markers were measured.Result 60 patients were enrolled (mean age=60±14.8y, M/F=45/15, COPD/BA/ACOS=15/32/14). The rates (%) of high HHV DNA in saliva, meaning fatigue state, in COPD/BA/ACOS were 40/36/30, for both viruses equally. aSITH-1Ab positive rates (%) in COPD/BA/ACOS were 15.8/57.9/26.3. The markers for systemic inflammation were higher in COPD/ACOS than BA alone.Conclusion 30∼40% of the patients with COPD/BA/ACOS were estimated as fatigue. The patients with COPD (COPD/ACOS) showed higher systemic inflammation than BA alone, whereas those with BA (BA/ACOS) showed higher prevalence of mental disturbance than COPD alone.1) Kondo K. et al. Journal of Virology 2002; 76: 4145-41512) Kondo K. et al. US Patent Application US 2013/0137088 A1 May 30, 2013.