RT Journal Article
SR Electronic
T1 An examination of the factors for successful pleurodesis against malignant pleural effusion (MPE)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA5085
DO 10.1183/13993003.congress-2016.PA5085
VO 48
IS suppl 60
A1 Suzuki, Eriko
A1 Yuichiro, Takeda
A1 Haruhito, Sugiyama
A1 Masayuki, Hojo
A1 Shinyu, Izumi
A1 Motokazu, Ikura
A1 Go, Naka
A1 Manabu, Suzuki
A1 Konomi, Kobayashi
A1 Ayako, Shiozawa
A1 Shota, Yamamoto
A1 Tomoyuki, Suzuki
A1 Keita, Sakamoto
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA5085.abstract
AB Background: OK-432 has been widely used in Japan for pleurodesis against MPE. Recently, TALC was able to use for pleurodesis against MPE under approval of Japanese medical insurance.Aim: To examine clinical factors for successful pleurodesis.Methods: We reviewed the medical record of patients who underwent pleurodesis against MPE from September 2010 to January 2016. A case without recurrent MPE during 30 days after the procedure was defined as a successful one. We also analyzed patient characteristics and adverse events.Results: Fifty nine trials of plurodesis for a total of 46 patients were performed during the period. The median age of patients was 70 (45 - 97) years old, male / female = 27 / 19, PS 0 / 1 / 2-3 / 4 = 2 / 39 / 17 / 1. Lung cancer, pleural mesothelioma, thymic cancer, and others were 37, 4, 1, and 4, respectively. Sixteen patients had TALC, 8 had OK-432, and 34 had OK-432 with minocycline. Two patients underwent pleurodesis for three times and 9 for twice, respectively. Five patients accomplished the procedure without removing the thoracic tube. The success rate was 31 % (5 / 16) in TALC group, 37.5 % (3 / 8) in OK-432 group, and 79 % (27 / 34) in OK-432 with minocycline group.Conclusion: In this study, OK-432 with minocycline group achieved high success rate of pleurodesis. We estimate that effective pleurodesis was provided when stronger inflammation happened to pleura by adding Minocycline to OK-432. As there is a deflection in the number of cases, we intend to perform a further research in the future. We are going to perform multivariate analysis to find clinical useful factors for successful pleurodesis against MPE.