TY - JOUR T1 - The association between gastritis/gastroesophageal reflux and rhinitis/rhinosinusitis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA4255 VL - 48 IS - suppl 60 SP - PA4255 AU - Francesca Locatelli AU - Eliana Finocchio AU - Alessandro Marcon AU - Roberto Bono AU - Isa Cerveri AU - Pietro Pirina AU - Giulia Trucco AU - Mario Olivieri AU - Marcello Ferrari AU - Giuseppe Verlato Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA4255.abstract N2 - Background: Gastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of the association is still debated.Aims: To evaluate the strength of the association between gastritis/GERD and rhinitis/sinusitis/rhinosinusitis.Methods: We investigated 1924 subjects aged 20-84 years, who underwent a clinical visit in four Italian centres (Torino, Pavia, Verona, Sassari) within the study on Gene Environment Interactions in Respiratory Diseases, a population-based multicase-control study. Subjects were asked if they had doctor-diagnosed “gastritis or stomach ulcer (confirmed by gastroscopy)” or “gastroesophageal reflux disease, hiatal hernia or esophagitis”. The association between rhinitis/sinusitis/rhinosinusitis and either gastritis or GERD was evaluated through relative risk ratios (RRR) by multinomial logistic regression.Results: The prevalence of gastritis increased from subjects without nasal disturbances (14.8%=133/766) to subjects with rhinitis (19.9%=154/775) and further to subjects with sinusitis (29.4%=30/102) or rhinosinusitis (29.7%=73/246). A similar pattern was observed as regards GERD, which was 14.1% in controls and increased to 21.0%, 24.5%, 31.3% respectively in subjects with rhinitis, sinusitis, rhinosinusitis. When adjusting for centre, sex, age, BMI, education, physical activity, smoking habits and alcohol intake, the RRR of rhinosinusitis was more than doubled in subjects with gastritis (2.1, 95% CI 1.4-3.0) or GERD (2.3, 1.6-3.2), compared to controls.Conclusion: The study confirmed the association between gastritis/GERD and nasal disturbances, which was particularly strong when considering rhinosinusitis. ER -