RT Journal Article
SR Electronic
T1 Identification of oxidative stress markers and their association with inflammation in smokers and early chronic obstructive pulmonary disease (COPD)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3785
DO 10.1183/13993003.congress-2016.PA3785
VO 48
IS suppl 60
A1 Laura Caram
A1 Renata Ferrari
A1 Duelele Nogueira
A1 Flavia Nogueira
A1 Katina Souza
A1 Nayara Arruda
A1 Mariana Braz
A1 Suzana Tanni
A1 Camila Corrêa
A1 Irma Godoy
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA3785.abstract
AB Introduction: Association between systemic inflammation and oxidative markers in smokers and in early COPD patients is not clear.Aims and Objectives: Our aim was to evaluate and correlate systemic inflammation, oxidative stress, total antioxidant status ad DNA damage and their relationship in smokers, mild/moderate COPD and never smokers.Methods: We evaluated 32 smokers (smoking history> 10 pack/years), 32 mild/moderate COPD patients and 32 never smokers. Concentrations of malondialdehyde (MDA), DNA damage (nucleoids - cometa assay), total antioxidant capacity (TAP) and C-reactive protein (CRP) were measured in serum.Results: Results showed higher concentrations of MDA in smokers (p<0.001) and COPD (p<0.001) when compared to never smokers, without statistically significant difference between smokers and COPD patients. TAP (p=0.20) and DNA damage (p=0.92) did not differ between groups. We identified positive association of smoking (p=0.02) and CRP (p=0.01) with MDA. The presence of smoking (p=0.02) showed negative correlation with TAP.Conclusion: Increased markers of oxidative stress associated with systemic inflammation were identified in smokers and early COPD patients. Furthermore, smoking was associated with reduction of antioxidant performance. Difference between smokers and early COPD remains unclear.Financial support: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Foundation for the Support of Research in São Paulo State, grant no: 2012/22321-0).