PT  - JOURNAL ARTICLE
AU  - Laura Caram
AU  - Renata Ferrari
AU  - Duelele Nogueira
AU  - Flavia Nogueira
AU  - Katina Souza
AU  - Nayara Arruda
AU  - Mariana Braz
AU  - Suzana Tanni
AU  - Camila Corrêa
AU  - Irma Godoy
TI  - Identification of oxidative stress markers and their association with inflammation in smokers and early chronic obstructive pulmonary disease (COPD)
AID  - 10.1183/13993003.congress-2016.PA3785
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA3785
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA3785.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA3785.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Introduction: Association between systemic inflammation and oxidative markers in smokers and in early COPD patients is not clear.Aims and Objectives: Our aim was to evaluate and correlate systemic inflammation, oxidative stress, total antioxidant status ad DNA damage and their relationship in smokers, mild/moderate COPD and never smokers.Methods: We evaluated 32 smokers (smoking history> 10 pack/years), 32 mild/moderate COPD patients and 32 never smokers. Concentrations of malondialdehyde (MDA), DNA damage (nucleoids - cometa assay), total antioxidant capacity (TAP) and C-reactive protein (CRP) were measured in serum.Results: Results showed higher concentrations of MDA in smokers (p<0.001) and COPD (p<0.001) when compared to never smokers, without statistically significant difference between smokers and COPD patients. TAP (p=0.20) and DNA damage (p=0.92) did not differ between groups. We identified positive association of smoking (p=0.02) and CRP (p=0.01) with MDA. The presence of smoking (p=0.02) showed negative correlation with TAP.Conclusion: Increased markers of oxidative stress associated with systemic inflammation were identified in smokers and early COPD patients. Furthermore, smoking was associated with reduction of antioxidant performance. Difference between smokers and early COPD remains unclear.Financial support: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Foundation for the Support of Research in São Paulo State, grant no: 2012/22321-0).