RT Journal Article
SR Electronic
T1 The role of allergen immunotherpy in children with mild to moderate asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1240
DO 10.1183/13993003.congress-2016.PA1240
VO 48
IS suppl 60
A1 Filipovic, Djordje
A1 Djuric-Filipovic, Ivana
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA1240.abstract
AB Background: The morbidity associated with mild to moderate asthma is very high in developing countries. The aim of this study was to describe the role of allergen immunotherapy in prevention of asthma exacerbation and hospitalization in children with mild to moderate asthma.Methods: 59 asthmatic children were included in the study. 34 patients were received AIT drops plus standard pharmacotherapy while 29 children received only standard pharmacotherapy according to the GINA guideline. Efficacy was evaluated using rescue medication score, oral corticosteroids score and asthma symptoms score (chest tightness, shortness of breath, cough and wheezing) during the two years. We analysed results at the baseline, after the one and after two years of follow-up period.Results: Asthma score was decreased during the first year of treatment, with the tendency of further decrease in the second year of follow up period. The most important effects of SLIT were observed for the symptom of wheezing and night cough (X2=56,790; p<0,001, X2=56,142; p<0,001) only in the experimental group. Additional significant improvements were also observed for rescue medication (p<0,001) and oral corticosteroids (p<0,001). The rate of exacerbation in experimental group was significant lower in comparison with that rate in control group. The same improvement was found also in the hospitalization rate.Discussion: It has been already known that allergen immunotherapy reduce asthma and drug scores. In our study we found that AIT has a positive impact on asthma hospitalization and exacerbation rate in children with mild to moderate asthma. AIT can prevent development of severe asthma in children with mild to moderate asthma.