RT Journal Article
SR Electronic
T1 Normalised quadriceps muscle strength cut-points and mortality in COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA3044
DO 10.1183/13993003.congress-2016.OA3044
VO 48
IS suppl 60
A1 Jane Lydia Canavan
A1 Matthew Maddocks
A1 Samantha Kon
A1 Sarah Jones
A1 Claire Nolan
A1 Alex Labey
A1 Michael Polkey
A1 William Man
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/OA3044.abstract
AB Background: We have previously described clinically relevant cut-points for quadriceps maximal voluntary contraction normalised to height squared (QMVC/ht2: female <5.99kg/m2; male <8.30kg/m2) that predict inability to stand from sitting in patients with chronic respiratory disease (Canavan et al 2015 AJRCCM 192(3):395-7). The aim of this study was to further validate these cut-points in patients with COPD by determining their association with all-cause mortality.Methods: QMVC/ht2 of the dominant leg was measured in 729 patients with stable COPD between 2011-2015. Vital status was checked at 01/01/2016 and survival assessed using a Kaplan-Meier plot and a log-rank test for trend.Results: Patients (61% male) had a mean (SD) age 69 (10) years, BMI 28 (6) kg/m2, MRC dyspnoea score 3 (1) and FEV1 49 (21) % predicted. Baseline QMVC was 26 (10) kg / 9.43 (3.2) kg/m2. Overall, median follow-up was 961 days and 95 deaths (13%) occurred. The survival distributions were significantly different for patients above and below the cut points, X2 (1) = 4.895, p=0.027 (Figure 1). Mean survival time was 1468 days and 1227 days respectively.Conclusion: Quadriceps muscle voluntary contraction normalised to height squared is associated with survival in COPD, providing further evidence of the clinical relevance of previously identified cut-points.