PT - JOURNAL ARTICLE AU - Sead Zeynel AU - Sava Pejkovska AU - Biserka Kaeva AU - Zlatica Goseva AU - Zoran Arsovski AU - Elena Jovanovska TI - Outcome predictors of noninvasive ventilation in patients with respiratory failure due to chronic obstructive pulmonary disease AID - 10.1183/13993003.congress-2016.PA2184 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA2184 VI - 48 IP - suppl 60 4099 - http://erj.ersjournals.com/content/48/suppl_60/PA2184.short 4100 - http://erj.ersjournals.com/content/48/suppl_60/PA2184.full SO - Eur Respir J2016 Sep 01; 48 AB - Introduction: In the last two decades noninvasive ventilation (NIV) has become an integral part of the protocol for the treatment of patients with acute respiratory failure.Aim: To define the factors that lead to failure of treatment with NIV, in order to avoid the delay of treatment with invasive mechanical ventilation, thus enabling better clinical management of the affected patients.Methods: Retrospectively were analyzed 120 patients with type 2 chronic respiratory failure due to COPD exacerbation, treated with NIV. The following data were analyzed: demographics, laboratory data, Acute Physiology and Chronic Health Evaluation (APACHE) II score; respiratory rate; pH; pO2; pCO2. Acid-base status was evaluated at the beginning and 1 hour after NIV treatment.Results: On admission arterial pH levels were lower (p<0.05) and APACHE II score and pCO2 were higher (p<0.05) in the NIV failure group. Arterial pH was lower (p<0.05) and pCO2 and respiratory rate were higher (p<0.05) after 1 hour in the NIV failure group. Age showed no correlation with the success of NIV treatment.Conclusion: Patients with higher pH and lower pCO2 and APACHE II score at admission, and by improving of these parameters after 1 hour have better outcome from treatment with NIV.