TY - JOUR T1 - Clinical features of chronic obstructive pulmonary disease in never smokers JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA4168 VL - 48 IS - suppl 60 SP - PA4168 AU - Shin young Kim AU - Hyoung Kyu Yoon AU - Tai joon An AU - Chan kwon Park AU - Sei Won Kim Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA4168.abstract N2 - Background: COPD is the 4th leading cause of death all over the world and smoking is a major risk factor. However an estimated 10%∼12% of patients with COPD have never smoked and little is known about the clinical features of never smokers with COPD.Method: This study was performed in the Pulmonology department, 47 university hospital, from January 2012 to December 2015. All patients were diagnosed COPD with spirometry according to the GOLD criteria. And a written questionnaire was used for other medical records.Result: A total of 1488 patients were included in this study, 123(8.3%) were never smokers and 1365(91.7%) were ever smoker. Never smokers were more likely to be women(60.2%vs3.6%,P<0.001), and shown to have more exposure to passive smoking(30.3%vs19.1%,P=0.004), more tuberculosis, bronchial asthma in childhood(39.6%vs25.5,P=0.001, 64.6%vs46.9%,p<0.001) and more chronic sputum (78.3%vs66.5%,p=0.008). Never smokers reported higher BMI(23.67vs22.7,P=0.003), higher depression score(13.45vs7.65,p=0.027). Radiologic result showed that emphysema was common in smoker(17.4%vs41.6%,P<0.001), bronchiectasis was common in never smokers(21.7%vs4.5%,p<0.001). GOLDII/III made up 87.5% of never smokers but there was no significant difference in distribution of COPD grades between two groups. When compared with never smokers with mild to moderate COPD(GOLD I/II), never smokers with severe COPD (GOLD III/IV) were shown to have more occupational exposure(16.3%vs9.6%,P=0.043) and a lower BMI(P=0.034).Conclusion: This study revealed that never smokers made up a substantial proportion for COPD patients. It is important to understand differences of clinical features between two groups and apply in COPD treatment. ER -