PT  - JOURNAL ARTICLE
AU  - Michele Porzio
AU  - Andrea Mazzetta
AU  - Romain Kessler
AU  - Anne Olland
TI  - LATE-BREAKING ABSTRACT: Long-term consequences of central airways stenosis after lung transplantation
AID  - 10.1183/13993003.congress-2016.OA3331
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - OA3331
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/OA3331.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/OA3331.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Central airways stenosis after lung transplantation is a frequent but poorly understood complication. Objectives of our study were to evaluate if stenosis was associated with worse outcomes after transplant. Lung transplant recipients of a single center (Strasbourg, France) between April 2009 and August 2014 were retrospectively reviewed. 191 lung transplants were realized: 175 bilateral lung transplants, 15 single lung, 1 cardiopulmonary. 22 (13%) developed central airway stenosis requiring endobronchial treatment. All these patients were treated by endoscopic dilatation with balloon; 9 patients (43%) needed endobronchial stents. Survival in recipients with or without central airway stenosis was not different. Respiratory infections and duration of hospitalization were significantly increased in recipients with airway stenosis (p=0,006, p=0,048 respectively). Respiratory function tests showed a decreased forced expiratory volume in one second (FEV1, %pred) in recipients with central airway stenosis, despite endoscopic treatment. Central airway stenosis after lung transplantation was not associated with a worse survival in our experience, but it showed an impact on long term lung function and it was a risk factor for respiratory infections.Patients (n)Stenosis (22)W/o stenosis (153)pHospitalization length of stay (days)144,23±10996±820.048Episodes of infection (during 18 months)2,4±21,2±10.006TABLE 1