TY - JOUR T1 - Programmatic management of drug resistance tuberculosis: Outcome analysis of 200 patients in western part of Rajasthan, India JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA2673 VL - 48 IS - suppl 60 SP - PA2673 AU - Sunil Kumar AU - Kailash Sharma AU - K.C. Agarwal AU - Swetabh Purohit Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA2673.abstract N2 - Background and aims: In present study we investigated the treatment outcome of multidrug resistant tuberculosis (MDRTB) and patient related factors which affected the treatment outcome under programmatic conditions.Methods: It was prospective observational study done on subsequently enrolled 200 MDRTB patients at a tertiary care center in western part of Rajasthan, India. Treatment protocols, schedule for mycobacterial cultures and outcome definitions were adopted from programmatic guidelines (PMDT in India May, 2012).Results: We obtained following results, culture conversion rate: 73%; cure rate: 43.5%; treatment defaults: 18.5%; deaths: 24% and failure rate: 6%. Seven patients were switched to extensively drug resistant tuberculosis (XDRTB) regimen and nine patients were labelled as treatment completed but not cured. Predictors of positive outcome were, culture conversion within 3 months, unilateral or minimal disease on chest radiograph, and weight gain and radiological improvement at 6 months. Reasons for treatment defaults were adverse drug reactions, improper counseling, social stigma, myths, previous habits of default, wrong knowledge spread by quacks and disagreement with programme.Conclusion: We concluded that culture conversion is not a good indicator of successful outcome. Treatment defaults are major challenge for the programme. Proper counselling about drug resistant tuberculosis, need for regular treatment and the duration of treatment should be done at each level of the health care system. ER -