RT Journal Article
SR Electronic
T1 The effect of co-existent chronic heart failure (CHF) on lower limb muscle function in COPD: Propensity matched analysis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3587
DO 10.1183/13993003.congress-2016.PA3587
VO 48
IS suppl 60
A1 Veronica Delogu
A1 Claire M. Nolan
A1 Jane L. Canavan
A1 Sarah E. Jones
A1 Elizabeth J. Fletcher
A1 Samantha S.C. Kon
A1 Rachael A. Evans
A1 Rebecca Lane
A1 Jennifer K. Quint
A1 Derek Bell
A1 Martin R. Cowie
A1 William D. Man
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA3587.abstract
AB Background: Skeletal muscle dysfunction, particularly of the lower limbs, is well documented in both COPD and CHF. We hypothesized that co-existent CHF would have a negative impact upon lower limb muscle function in COPD.Methods: 40 patients with COPD+CHF (mean ejection fraction 39%) were matched to 40 COPD patients using propensity score matching taking into account age, sex, FEV1% and BMI. Quadriceps maximum voluntary contraction (QMVC), lower limb muscle performance measures (5 repetition sit to stand (5STS), 4 metre gait speed (4MGS)), exercise capacity (incremental shuttle walk (ISW)) and self-reported daily physical activity levels were compared.Results: Self-reported daily physical activity was similar between groups. No significant between group differences were seen in QMVC, 5STS, 4MGS or ISW (Table 1). VariableCOPD (Mean (SD) or Median (25th, 75th centile))COPD and CHF (Mean (SD) or Median (25th, 75th centile))Between group p valueSex (male:female)36:435:50.72Age(years)71(9)72(9)0.98FEV1(%)48.2(18.8)52.4(23.5)0.38Current smoker n(%)6(15)5(13)0.78MRC3(1)3(1)0.61BMI(kg/m2)29.3(7.4)28.4(6.3)0.58Daily mins spent in moderate intensity physical activity27(32)32(23)0.65ISW(m)180(130)187(141)0.81QMVC(kg)27.0(8.6)28.8(8.8)0.57QMVC/Height2(kg/m2)9.3(2.9)9.4(2.8)0.905STS(sec)15.38(11.59, 27.59)13.72(11.13, 19.52)0.494MGS(ms-1)1.13(0.95,1.46)1.10(0.89,1.51)0.91Group characteristicsConclusion: Co-existence of CHF did not impact on lower limb muscle strength or function in COPD. Skeletal muscle dysfunction in COPD and CHF may be due to a common aetiological factor (e.g. physical inactivity) rather than disease-specific factors.