PT  - JOURNAL ARTICLE
AU  - Veronica Delogu
AU  - Claire M. Nolan
AU  - Jane L. Canavan
AU  - Sarah E. Jones
AU  - Elizabeth J. Fletcher
AU  - Samantha S.C. Kon
AU  - Rachael A. Evans
AU  - Rebecca Lane
AU  - Jennifer K. Quint
AU  - Derek Bell
AU  - Martin R. Cowie
AU  - William D. Man
TI  - The effect of co-existent chronic heart failure (CHF) on lower limb muscle function in COPD: Propensity matched analysis
AID  - 10.1183/13993003.congress-2016.PA3587
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA3587
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA3587.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA3587.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Background: Skeletal muscle dysfunction, particularly of the lower limbs, is well documented in both COPD and CHF. We hypothesized that co-existent CHF would have a negative impact upon lower limb muscle function in COPD.Methods: 40 patients with COPD+CHF (mean ejection fraction 39%) were matched to 40 COPD patients using propensity score matching taking into account age, sex, FEV1% and BMI. Quadriceps maximum voluntary contraction (QMVC), lower limb muscle performance measures (5 repetition sit to stand (5STS), 4 metre gait speed (4MGS)), exercise capacity (incremental shuttle walk (ISW)) and self-reported daily physical activity levels were compared.Results: Self-reported daily physical activity was similar between groups. No significant between group differences were seen in QMVC, 5STS, 4MGS or ISW (Table 1). VariableCOPD (Mean (SD) or Median (25th, 75th centile))COPD and CHF (Mean (SD) or Median (25th, 75th centile))Between group p valueSex (male:female)36:435:50.72Age(years)71(9)72(9)0.98FEV1(%)48.2(18.8)52.4(23.5)0.38Current smoker n(%)6(15)5(13)0.78MRC3(1)3(1)0.61BMI(kg/m2)29.3(7.4)28.4(6.3)0.58Daily mins spent in moderate intensity physical activity27(32)32(23)0.65ISW(m)180(130)187(141)0.81QMVC(kg)27.0(8.6)28.8(8.8)0.57QMVC/Height2(kg/m2)9.3(2.9)9.4(2.8)0.905STS(sec)15.38(11.59, 27.59)13.72(11.13, 19.52)0.494MGS(ms-1)1.13(0.95,1.46)1.10(0.89,1.51)0.91Group characteristicsConclusion: Co-existence of CHF did not impact on lower limb muscle strength or function in COPD. Skeletal muscle dysfunction in COPD and CHF may be due to a common aetiological factor (e.g. physical inactivity) rather than disease-specific factors.