RT Journal Article
SR Electronic
T1 Hypogonadism as a factor influencing health condition in COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4616
DO 10.1183/13993003.congress-2016.PA4616
VO 48
IS suppl 60
A1 Renata Rubinsztajn
A1 Tadeusz Przybylowski
A1 Marta Maskey-Warzechowska
A1 Krzysztof Kartwat
A1 Ryszarda Chazan
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4616.abstract
AB Low serum testosterone (ST) concentration is associated with a worse general health condition. It is observed in some chronic diseases.The aim of the study was to evaluate the incidence of decreased ST concentration in male (M) COPD patients and its influence on their condition.The study group consisted of 90 M patients aged 67.2 ±8.8 years, in all stage of severity airflow limitation (GOLD 1 n=10, GOLD 2 n=39, GOLD 3 n=24 and GOLD 4 n=15). ST concentration was evaluated by ELISA metods. Decreased ST level was defined as a value of less than 3 ng/mL.Results ST concentration didn't differ in patients with different stages severity of airflow limitation (GOLD 1: 3.8±0.7 ng/mL, GOLD 2: 3.6±2.1 ng/mL, GOLD 3: 3.4± 1.2 ng/mL, GOLD 4: 3.7±1.7 ng/mL). Decreased ST was found in 30 patients - group A (33.3%). There were no differences in age. The important differences between studied groups are presentest in table 1View this table:TABLE 1 The following correlations between ST and the investigated variables were foundTestosteroneVariablerpSpO2 at rest (%)0.250.026MWD0.320.03post SABA FEV1 (%pred)0.230.02post SABA FEV1 (L)0.280.005post SABA FVC (L)0.230.02BMI kg/m2-0.250.01Ht (%)0.290.01Hb (g/dL)0.240.03TABLE 2 Conclusion: Hypogonadism may occur in as much as 30% of male COPD patients. The correlation between ST and negative COPD prognostic factors may suggest its influence on the natural history of the disease.