RT Journal Article
SR Electronic
T1 Long-term effects of CPAP on blood pressure in non-resistant hypertensive patients with obstructive sleep apnea: A 30 month prospective study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2082
DO 10.1183/13993003.congress-2016.PA2082
VO 48
IS suppl 60
A1 Oana Claudia Deleanu
A1 Corina Ioana Oprea
A1 Andra Elena Malaut
A1 Ana Maria Zaharie
A1 Miruna Mihaela Micheu
A1 Natalia Patrascu
A1 Florin Dumitru Mihaltan
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA2082.abstract
AB OBJECTIVE: Previous studies related to evolution of blood pressure (BP) under CPAP therapy in patients with obstructive sleep apnea (OSA) associating hypertension (HT) had a duration of follow up no longer than 12 months.Purpose: To study the variation of 48h BP (using ambulatory blood pressure monitoring ABPM) after 3, 6, 12 and 30 months of CPAP in moderate-severe OSA (PSG) compliant to therapy (CPAP manual titration) and hypertension (HT) under stable antiHT treatment.METHODS: We excluded patients with other sleep pathologies, secondary HT, resistant HT, acute/uncontrolled pathologies, changing medication during the study.RESULTS: 134 patients screened; 7 HT patients (7.42±4.19 years from HT diagnosis) of 96 enrolled with OSA were evaluated at 30 months, 6 men (85.7%). Baseline mean values: age 65.00±12.38 years, BMI 31.38±7.03kg/m2, Epworth score 10.28±4.42/h, diagnostic AHI 55.44±29.26/h, oxygen desaturation index70.71±13.30/h, AHI post-titration 10.34±8.89/h, 48h systolic BP (SBP) baseline 147.42±20.2mmHg, diastolic BP (DBP) 78.14±9.22mmHg. In evolution: no changes in BMI or compliance. After 30 months significant improvements (p<0.05) of all ABPM parameters were recorded: 48h SBP decreased with 26.71mmHg (95% CI 8.57-44.85, p=0.008) and 48h DBP decreased with 12.43mmHg (95% CI 2.48-22.36, p=0.018).CONCLUSION: This is the first study that followed compliant OSA and HT patients for 30 months. The study demonstrated reduction in BP much superior to those previously reported, high-lightening the importance in terms of cardiovascular risk of a proper used of CPAP therapy for a long period of time in patients with OSA and HT.