RT Journal Article
SR Electronic
T1 Prevalence of refractory asthma in population with severe asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4180
DO 10.1183/13993003.congress-2016.PA4180
VO 48
IS suppl 60
A1 Evgeny Kulikov
A1 Ludmila Ogorodova
A1 Ivan Deev
A1 Natalya Kirillova
A1 Sergey Fedosenko
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4180.abstract
AB Background: Severe persistent asthma is associated with high morbidity, among patients with severe asthma, higher risks can be expected in patients with refractory asthma, but little is known about clinical factors which associated with refractory (therapy-resistant) asthma.Aims and objectives: To compare prevalence and clinical characteristics of refractory asthma in severe asthma population.Methods: Prospective, interventional, controlled study in parallel groups with 6 month treatment period was performed. Patients with severe uncontrolled disease and appropriate (GINA) treatment administered were included in the study. According to treatment response patients were aposterior divided according to ATS 200 criteria into groups of severe or refractory asthma.Results and conclusion: Initially, in the group of refractory asthma worse clinical and functional parameters of asthma course were registered compared with severe asthma. According to our data the prevalence of refractory asthma in population with severe asthma is more than 50%.ParameterSevere asthma (n=19)Refractory asthma (n=21)Age, years47,15±3,2051,40±2,52Day symptoms per week12,45±1,5121,35±2,13*Night symptoms per week2,55±0,475,05±1,15Disease duration, years9,75±1,9416,65±1,88*Age of disease manifestation33,30±3,9128,15±3,78Frequency of emergency calls per year0,15±0,152,60±1,23*Number of visits to the doctor per year3,40±1,102,95±0,96FEV1, %68,10±1,8961,97±1,97*PEF, %73,84±3,5668,51±2,82FVC87,61±2,8285,10±2,95Reversibility, %FEV124,94±1,9631,27±2,99ACT score15,30±0,5812,40±0,89**-p<0.05Clinical characteristics of refractory asthma in comparison with severe asthma