PT  - JOURNAL ARTICLE
AU  - Liudmila Zhelenina
AU  - Alevtina Bogdanova
AU  - Svetlana Starevskaya
AU  - Ilgar Mustafaev
AU  - Juriyi Gorelik
AU  - Mariya Kuropatenko
TI  - Twenty years of research into bronchopulmonary dysplasia
AID  - 10.1183/13993003.congress-2016.OA1499
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - OA1499
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/OA1499.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/OA1499.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Bronchopulmonary dysplasia (BPD) develops in prematurely born babies while on treatment for respiratory disorders, which considerably affects infant mortality rate and further respiratory function in adolescents and adults.Aim. Research was conducted in order to determine clinical and radiologic peculiarities, to assess the severity of lesions in small bronchi and interstitial tissue, inflammatory characteristics, and long-term outcomes of the disease.Materials. 143 children were examined. 76.7% were born with extremely low weight. Morphology study was performed in 10 children with BPD; inflammatory characteristics were assessed in 24 children. Cytokine profile and GITR were determined in children under 3 yrs. CT of the lungs was performed to 52 children under 17 yrs; 64 children underwent a complex examination of respiratory function.Results. Cytomorphology study of bronchial lavages revealed evidence of inflammation manifested in neutrophiles and lymphocytes with flat epithelial metaplasia. Percentage of CD3 was significantly decreased in the exacerbation phase (48,6±0,7) and considerably increased in the remission phase (55,2±0,6). Concentration of Il4 in the exacerbation period exceeded the upper limit of norm by 1.5 times (21,0±0,6), which then normalized and entered the remission stage. In catamnesis, only 1/3 of children had normal values for respiratory function. Obstructive changes were found in 66%, residual lung volume was increased in 49%, restrictive changes did not exceed 6% of cases.Conclusion: clinical course of BPD has been similar to the new BPD in recent years; catamnesis has evidence of bronchial hyperreactivity with minimal organic changes in the lungs.