RT Journal Article
SR Electronic
T1 Human bocavirus and respiratory tract infection in hospitalized children
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1274
DO 10.1183/13993003.congress-2016.PA1274
VO 48
IS suppl 60
A1 Laura Petrarca
A1 Raffaella Nenna
A1 Antonella Frassanito
A1 Alessandra Pierangeli
A1 Giulia Cangiano
A1 Isabella Calicchia
A1 Lelia Lo Russo
A1 Chiara Di Mario
A1 Giulia Faiola
A1 Fabio Midulla
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA1274.abstract
AB Introduction: Bovavirus(HBoV) was identified for the first time in 2005, however its role as a respiratory pathogen has not been fulfilled yet.Our aim was to describe clinical and serological characteristics of hospitalized children with HBoV and its effect on follow-up.Methods: We restrospectively reviewed data from 44 children(21 males median age 149days, age range:15-859days) in which HBoV1 was detected from nasopharyngeal washing, using a real-time PCR. All children were hospitalized for acute respiratory symptoms at the Paediatric Department, “Sapienza” University of Rome.One year after discharge, an interview was performed seeking information on recurrent wheezing.Results: A single virus was detected in a half of samples, and in an another half a co-infection with other viruses was observed(16 HBoV+RSV, 2 RV+HBoV, 1 HBoV+Para1,1 MPV+HBoV, 1 Adeno+RV+HBoV,1 RSV+RV+HBoV).32(72.7%)children had bronchiolitis, 6(13.6%) acute wheezing, 2(4,5%) pneumonia, 2(4,5%)upper respiratory tract infection and 2(4,5%)whooping cough. 33 patients performed a Chest X-Ray:10(30,3%)were normal, 23(69,7%)showed a consolidation.39(98,6%) children had one or more siblings, 10(22,7%) presented a family history positive for asthma, and 10(22,7%) for atopy.After 12 months from the hospitalization 20/34(58,8%) presented recurrent wheezing.No differences were observed in terms of sex, positive family history for atopy and/or asthma, clinical presentation, consolidation on Chest X-Ray, and laboratory findings between children HBoV alone vs co-infection.Conclusion: HBoV can be detected from nasopharyngeal samples of children affected by acute respiratory tract infection, with no differences between children HBoV alone vs co-infection.