TY - JOUR T1 - Human bocavirus and respiratory tract infection in hospitalized children JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA1274 VL - 48 IS - suppl 60 SP - PA1274 AU - Laura Petrarca AU - Raffaella Nenna AU - Antonella Frassanito AU - Alessandra Pierangeli AU - Giulia Cangiano AU - Isabella Calicchia AU - Lelia Lo Russo AU - Chiara Di Mario AU - Giulia Faiola AU - Fabio Midulla Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA1274.abstract N2 - Introduction: Bovavirus(HBoV) was identified for the first time in 2005, however its role as a respiratory pathogen has not been fulfilled yet.Our aim was to describe clinical and serological characteristics of hospitalized children with HBoV and its effect on follow-up.Methods: We restrospectively reviewed data from 44 children(21 males median age 149days, age range:15-859days) in which HBoV1 was detected from nasopharyngeal washing, using a real-time PCR. All children were hospitalized for acute respiratory symptoms at the Paediatric Department, “Sapienza” University of Rome.One year after discharge, an interview was performed seeking information on recurrent wheezing.Results: A single virus was detected in a half of samples, and in an another half a co-infection with other viruses was observed(16 HBoV+RSV, 2 RV+HBoV, 1 HBoV+Para1,1 MPV+HBoV, 1 Adeno+RV+HBoV,1 RSV+RV+HBoV).32(72.7%)children had bronchiolitis, 6(13.6%) acute wheezing, 2(4,5%) pneumonia, 2(4,5%)upper respiratory tract infection and 2(4,5%)whooping cough. 33 patients performed a Chest X-Ray:10(30,3%)were normal, 23(69,7%)showed a consolidation.39(98,6%) children had one or more siblings, 10(22,7%) presented a family history positive for asthma, and 10(22,7%) for atopy.After 12 months from the hospitalization 20/34(58,8%) presented recurrent wheezing.No differences were observed in terms of sex, positive family history for atopy and/or asthma, clinical presentation, consolidation on Chest X-Ray, and laboratory findings between children HBoV alone vs co-infection.Conclusion: HBoV can be detected from nasopharyngeal samples of children affected by acute respiratory tract infection, with no differences between children HBoV alone vs co-infection. ER -