PT - JOURNAL ARTICLE AU - Tatsiana Rybina AU - Volha Kardash AU - Siarhei Semizhon AU - Victor Zaitsev AU - Aliaxandra Rybina AU - Hleb Kardash TI - Lung function and element status of foundry workers AID - 10.1183/13993003.congress-2016.PA4284 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA4284 VI - 48 IP - suppl 60 4099 - http://erj.ersjournals.com/content/48/suppl_60/PA4284.short 4100 - http://erj.ersjournals.com/content/48/suppl_60/PA4284.full SO - Eur Respir J2016 Sep 01; 48 AB - Processes in the foundry production involve the potential hazards for inhalation exposures that may lead to respiratory diseases, metabolic disorders of trace elements. However, the dependence of lung dysfunction on the metal toxicity is unclear.The aim of this study was to investigate the effects of industrial aerosol exposure on lung ventilation function depending on trace element accumulation.Methods We analyzed 2 groups of foundry employees (58 men and 10 women): with work experience of up to 3 years (gr. 1) and more than 5 years (gr. 2). Unexposed workers (uew - 19 persons) served as a control. The mean age was 36.9±13.4 yrs for uew and 37.7 ± 1.5 yrs for foundry workers.Determination of metals and metalloids in hair samplings was done by atomic emission spectrometry (Ultima 2, Japan-France). The pulmonary function was recorded by spirometry(MAS-1, Belarus) according to the standards of the ERS. Statistical analysis was performed using the software package Statistica 6.0 (StatSoft Inc., USA).Results Significant rises in manganese accumulation have been found in both groups of foundry workers (84.8% and 79.4%, respectively in gr. 1 and gr. 2, p=0.76). Elevated manganese concentration was determined in 5.3% of the control group workers (p <0.001 compared with gr.1 and gr. 2). Lung ventilation dysfunction was observed in 9% of gr. 1 and 44% of gr. 2 (p=0.035).Conclusion Lung ventilation dysfunction occurs in the exposed (more than 5 years) foundry workers. Elevated manganese accumulation under the influence of industrial aerosols does not depend on the duration of the work experience. These effects indicate a need for personalized prevention for foundry workers at the any duration of exposure to industrial aerosols.