RT Journal Article
SR Electronic
T1 Postnatal corticosteroids and lung function at school age in very prematurely born infants
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA247
DO 10.1183/13993003.congress-2016.OA247
VO 48
IS suppl 60
A1 Christopher Harris
A1 Sanja Zivanovic
A1 Mireia Alcazar-Paris
A1 Jessica Lo
A1 Alan Lunt
A1 Neil Marlow
A1 Sandra Calvert
A1 Janet Peacock
A1 Anne Greenough
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/OA247.abstract
AB Background: Postnatal steroids reduce the incidence of BPD in very prematurely born children, but studies of their impact on lung function in childhood have yielded conflicting resultsAims and objectives: To assess the influence of postnatal corticosteroids on lung function of very prematurely born children aged 11-14 years.Methods: Lung function was assessed in 244 children (born median gestational age of 27+0 (23+6-28+6) weeks) at 12.5 (range 11.3-14.9) years. Airway function was assessed by measurement of forced expiratory flow at 75%, 50% and 25% of the expired vital capacity (FEF25, FEF50, FEF75), forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF). Lung volumes were assessed by forced vital capacity (FVC) and residual volume (RV) and functional residual capacity by plethysmography (FRCpleth).Results: Airway function and the lung volumes of the 68 children who had been exposed to steroids differed significantly from those not exposed Steroid ExposureLung FunctionNNoYesP valueFEF75 z score244-0.937 (0.89)-1.442 (0.76)<0.001FEF50 z score244-1.040 (0.87)-1.691 (0.81)<0.001FEF25 z score244-0.814 (0.89)-1.490 (0.85)<0.001FEF25-75 z score227-1.245 (1.02)-2.016 (1.01)<0.001FEV1 z score244-0.549 (0.97)-1.371 (1.08)<0.001FVC z score244-0.237 (0.91)-0.699 (1.07)0.001FEV1:FVC z score244-1.166 (1.59)-2.203 (2.04)<0.001PEF % of predicted24385.7 (15.0)77.4 (14.4)<0.001RV z score2070.149 (0.08)1.172 (0.22)<0.001FRCpleth z score214-0.226 (0.09)0.325 (0.19)0.005Data are expressed as the mean (SD)Lung Function and Steroid ExposureConclusion: These results suggest postnatal corticosteroids have long term adverse effects on lung function in this population.