PT  - JOURNAL ARTICLE
AU  - Avinash Jain
AU  - S.K. Agrawal
TI  - Significance of quantitative radiological phenotypes of COPD on BODE index
AID  - 10.1183/13993003.congress-2016.PA4175
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA4175
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA4175.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA4175.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Background: Significant Heterogeneity of Clinical Presentation and Disease Progression exists within COPD. The Goal of Phenotyping is to identify patient groups with unique Prognostic or Therapeutic Characteristics.Quantitative HRCT (QHRCT) provides unique COPD Phenotyping information.Objective: We hypothesized that QHRCT-defined Emphysema and Airway Abnormalities influence BODE index.Methods: 106 COPD subjects meeting Global Initiative for Chronic Obstructive Lung Disease (GOLD)2 criteria for COPD with QHRCT analysis were included. Total lung emphysema was measured using the Density Mask Technique with a −950 Hounsfield unit threshold. An visual Semi-Automated Quantification of Mean Wall Thickness (WT), Wall Area Percentage (WA%) in 6 Segmental Bronchi. Multivariate Modeling compared Emphysema severity and Airway Abnormality on Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index measure.Results: 1 unit SD increase Emphysema Percentage more strongly influenced BODE (range 1.23-fold increase, p<0.001). 1 unit SD increase in each airway measure predicted BODE scores (for WT, 1.04-fold increase, p<0.001; for WA%1.18-fold increase, p<0.001).Conclusion: QHRCT is complimentary tool to evaluate progression of COPD. Emphysema and Airway disease both relate to clinically important parameters. Emphysema is a stronger predictor of BODE and Its systemic components MMRC, 6MWT, and BMI than Airway Abnormalities.Reference: 1-Clinical analysis of chronic obstructive pulmonary disease phenotypes classified using high-resolution computed tomographyK Fujimoto, Y Kitaguchi, K Kubo, - Respirology, 20062- GOLD Definition 2016www.goldcopd.com.