%0 Journal Article %A Jiayuan Sun %A Lei Wang %A Xiaowei Mao %A Xiaoxuan Zheng %A Baohui Han %T Endobronchial ultrasound elastography for the prediction of malignant intrathoracic lymph nodes during EBUS-TBNA %D 2016 %R 10.1183/13993003.congress-2016.PA2045 %J European Respiratory Journal %P PA2045 %V 48 %N suppl 60 %X Background: Endobronchial ultrasound (EBUS) elastography is a new imaging procedure for describing elasticity of intrathoracic lesions. Here the ability of EBUS elastography to differentiate between benign and malignant lymphnodes(LNs) during EBUS-guided transbronchial needle aspiration (TBNA) was be evaluated by the qualitative and quantitative methods.Methods: Patients with enlarged intrathoracic LNs required for EBUS-TBNA examination were prospectively included at a clinical center for thoracic medicine from January 2014 to April 2014.EBUSsonographic characteristics on B-mode, vascular patterns and elastography, EBUS-TBNA procedures, pathologic findings, and microbiologic results were recorded. The elastographic patterns (qualitative method) and the mean gray value inside the region of interest(quantitative method) were analyzed. Both methods were compared with a definitive diagnosis of the involved LNs.Results: Of the 58 patients(70LNs)prospectively enrolled, 2 patients (2LNs) were excluded because of loss of follow up.56 patients including 68 LNs(33 benign and 35 malignant nodes)were retrospectively analyzed. Using the qualitative and quantitative methods, we were able to differentiate between benign and malignant LNs with a high sensitivity, specificity, positive and negative predictive values, and accuracy(85.71%, 81.82%,83.33%, 84.38%, 83.82% vs 91.43%, 72.73%, 78.05%, 88.89%,82.35%, respectively).Conclusions: EBUS elastography is potentially capable of further differentiating between benign and malignant LNs. The proposed qualitative and quantitative methods might be useful tools for describing EBUS elastography during EBUS-TBNA. %U