TY - JOUR T1 - Effectiveness of pulmonary rehabilitation in different COPD stages JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA687 VL - 48 IS - suppl 60 SP - PA687 AU - Maria Kerti AU - Zsuzsanna Balogh AU - Krisztina Kelemen AU - Janos Varga Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA687.abstract N2 - Rationale: Pulmonary rehabilitation can improve exercise tolerance, symptoms, muscle function and lung mechanics.Aims: The Aim of the study was to investigate what is the effectiveness of pulmonary rehabilitation in different stages of COPD.Materials and methods: 201 patients with COPD (GOLD stage I, n=21, FEV1: 86±13 %pred; stage II, n=41, FEV1: 61±7 %pred; stage III, n=78, FEV1: 40±7 %pred; stage IV, n=61, FEV1: 23±4 %pred) participated in this study. Patients performed a complex pulmonary rehabilitation program with chest wall-stretching, controlled breathing techniques and training, and personalized exercise training 2-3 times for 20-30 minutes per day by cycling and treadmill for 4 weeks. 6 minutes walking distance (6MWD), Modified Medical Research Dyspnea Scale (mMRC), COPD Assessment test (CAT), lung function, chest wall expansion (CE), maximal inspiratory pressure (MIP) and breath holding time were measured.Results: Rehabilitation resulted improvement in 6MWD (stage I: 423±94 vs. 485±85m*, stage II: 357±85 vs. 413±85*; stage III: 361±88 vs. 416±85; stage IV: 314±91 vs. 373±97m*, *p<0,05), CAT (stage I: 14±6 vs. 8±6*, stage II: 16±6 vs. 8±6*, stage III: 17±7 vs. 10±7*, stage IV: 20±6 vs 14±6*, *p<0,05) and CE (stage I: 5,00±1,81 vs. 6,98±1,91cm*; stage II: 3,92±1,82 vs. 5,73±199*, stage III: 3,89±1,94 vs. 5,53±1,96*; stage IV: 3,48±1,61 vs. 5,0±1,71*, * p<0,05). Lung function, mMRC, MIP and breath holding time did not change significantly in the different stages.Conclusion: PR was effective in improvement of exercise tolerance, lung mechanics and quality of life in all stages, except 6MWD in stage III. A longer rehabilitation time may need to achieve significant changes in the other markers. ER -