PT  - JOURNAL ARTICLE
AU  - Thitiwat Sriprasart
AU  - Alex Aragaki
AU  - Sadia Benzaquen
TI  - Safety and diagnostic yield of transbronchial cryobiopsy
AID  - 10.1183/13993003.congress-2016.PA4667
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA4667
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA4667.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA4667.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Background: Transbronchial cryobiopsy (TBCB) have been used for establishing the diagnosis of interstitial lung disease( ILD). However, the safety and diagnostic yield are variable. We reported our safety and diagnostic yield data.Methods: This is a retrospective chart review of iILD patients who underwent TBCB for evaluation of ILD other than sarcoidosis. The demographic data, diagnosis and complications were collected.Results: 57 patients underwent TBCB. The mean age 56.39 years. The mean tissue area was 58.67 mm2. Median anesthesia time was 87 minutes. The diagnostic yield was 85.96%. The most common diagnosis was usual interstitial pneumonia(12 cases). revealed the diagnosis made by TBCB. Pneumothorax occurred in 3 cases (5.26%). There was one case with bronchoscopic related respiratory failure.DiagnosisNumberUsual Interstitial Pneumonia12Nonspecific Interstitial Pneumonia8Hypersensitivity Pneumonitis6Organizing Pneumonia10Capillaritis2DIP1RB-ILD3Diffuse Alveolar Hemorrhage1Malignancy(adenocarcinoma, CLL)3Others(PLCH, infections)3Non diagnosis8Diagnosis made by transbronchial cryobiopsyDiscussion: TBCB has been used in patients with ILD. In the Babiakl1 study, the specimen size was 11 mm2 with pneumothorax 4.9%. In Pajares study 2 the specimen size, diagnostic yield and pneumothorax were 14.7mm2, 74.4%, and 8% respectively. In our report, the specimen area was quite larger than previous reports with diagnostic yield above 85% and comparable pneumothorax rate.Conclusion: In our experience, TBCB provided reasonable diagnostic yield and safety in diagnosing ILDs.Reference: 1. Babiak A et al. Respiration 2009; 78(2): 203-208. 2. Pajares V et al. Respirology 2014; 19(6): 900-906.