RT Journal Article
SR Electronic
T1 Obstructive sleep apnea in adults with Down syndrome
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2333
DO 10.1183/13993003.congress-2016.PA2333
VO 48
IS suppl 60
A1 Layla Diab Caceres
A1 Carmen Acosta
A1 Pedro Landete
A1 Enrique Zamora
A1 Joan B. Soriano
A1 Julio Ancochea
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA2333.abstract
AB Introduction: Down syndrome(DS), due to the anatomy of their upper airways, have a high prevalence of obstructive sleep apnea-hypopnea(OSA), this relation has been little studied. We aimed to determine the prevalence, clinical and polygraphic features ofOSA, and their changes after the start of treatment.Material and methods: Observational study design, consecutive DSpatients with suspectedOSA were included, being referred because of excessive daytime sleepiness and cognitive impairment. A complete sleep history assesment and either polygraphy(PG) or polysomnography(PSG) were conducted.Results: 47 patients were studied,60% male, age of35±10 years, BMI30±6 kg/m2, neck circumference41±4 cm. The Epworth score was13±5. PG was performed in92%, andPSG in the other8%, resulting 7% normal, 7% mild,41% moderate and45% severe OSA, with an AHI of38±31h-1, dominated by events in supine position(56±33), ODI33.6±28h-1, minimum oxygen saturation79±10%, shorter than90% of saturation22±24%. Treatment was started withCPAP in 25(53.2%), with a pressure of7±2 cmH2O, 72% of them had good adaptation and compliance, resulting with improvement in52% after6 months.MallampatiClass I5.1%Class II12.8%Class III38.5%Class IV43.6%SymptomsSnorer89.4%Daytime Sleepiness80.9%Headaches10%Behavior change40.4%Observed Apneas31.9%Poligraphyc StudyI. Obstructive22±10 h-1I. Hypopneas16 ±12 h-1I. Mixed4±2 h-1I. Central12±5 h-1Clinical characteristics associated with OSAConclusions: OSA was diagnosed in93%;42% of them had severe OSA, with a high prevalence of respiratory events in supine position. CPAP treatment was started in more than half, with an objective improvement in52% of patients.