TY - JOUR T1 - The functional state of the diaphragm in COPD patients with hypoxemia JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA4621 VL - 48 IS - suppl 60 SP - PA4621 AU - Vladimir Volchkov AU - Olga Titova AU - Darya Sklyarova AU - Natalia Kusubova Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA4621.abstract N2 - Background: Diaphragmatic dysfunction is one of the most important reasons for dyspnea in patients with COPD(chronic obstructive pulmonary disease).The aim of the study was to determine the functional state of the diaphragm in COPD patients with chronic respiratory failure.Methods: We studied 60 patients with COPD GOLD III and IV in remission. The patients were divided into two groups: 1 group – 26 patients with hypoxemia (paO2=53,9±5.9 mm Hg), group 2 – 34 patients without hypoxemia (paO2= 81,05±12.8 mm Hg). Both groups had no significant differences in FEV1, echocardiographic parameters. The sonographic measurements of the diaphragm were performed.Results: COPD patients with hypoxemia showed a trend toward lower speed of relaxation of the muscular part of the diaphragm. Fraction of the thickening of the muscular part of the diaphragm during quiet and forced breathing was also significantly lower in patients of Group 1. In addition, the decreasing speed of contraction of the muscular part of the diaphragm was detected in patients with hypoxemia.There was a negative correlation between paO2 and speed of contraction of the muscular part of the diaphragm during quiet (r= 0,61; p<0,05) and forced breathing (r= - 0,42; p<0,05) in patients of Group 1.Conclusion: In patients with hypoxemia appear functional abnormalities of the diaphragm. Process of the relaxation of the muscles and fraction of the thickening of the muscular part of the diaphragm are the most sensitive indicators of the diaphragmatic disfunction. It indicates the exhaustion of compensatory possibilities and progression of the muscle fatigue of the diaphragm in COPD patients with hypoxemia. ER -