RT Journal Article
SR Electronic
T1 The effect of smoking on lung function: a clinical study of adult-onset asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1298
OP 1306
DO 10.1183/13993003.00850-2016
VO 48
IS 5
A1 Tommola, Minna
A1 Ilmarinen, Pinja
A1 Tuomisto, Leena E.
A1 Haanpää, Jussi
A1 Kankaanranta, Terhi
A1 Niemelä, Onni
A1 Kankaanranta, Hannu
YR 2016
UL http://erj.ersjournals.com/content/48/5/1298.abstract
AB The aim of this study was to evaluate the effect of smoking on lung function decline in adult-onset asthma in a clinical, 12-year follow-up study.In the Seinäjoki Adult Asthma Study, 203 patients were followed for 12 years (1999–2013) after diagnosis of new-onset adult asthma. Patients were divided into two groups based on smoking history: <10 or ≥10 pack-years. Spirometry evaluation points were: 1) baseline, 2) the maximum lung function during the first 2.5 years after diagnosis (Max0–2.5) and 3) after 12 years of follow-up.Between Max0–2.5 and follow-up, the median annual decline in absolute forced expiratory volume in 1 s (FEV1) was 36 mL in the group of patients with <10 pack-years of smoking and 54 mL in those with smoking history ≥10 pack-years (p=0.003). The annual declines in FEV1 % pred (p=0.006), forced vital capacity (FVC) (p=0.035) and FEV1/FVC (p=0.045) were also accelerated in the group of patients with ≥10 pack-years smoked. In multivariate regression analysis, smoking history ≥10 pack-years became a significant predictor of accelerated decline in FEV1.Among patients with clinically defined adult-onset asthma, smoking history ≥10 pack-years is associated with accelerated loss of lung function.In adult-onset asthma, smoking history ≥10 pack-years is associated with accelerated loss of lung function http://ow.ly/zZep302fJob